GPS1 and COPS7A

Number of citations of the paper that reports this interaction (PubMedID 11285227)
43

Data Source:
HPRD (in vitro)

		GPS1	COPS7A
Description		G protein pathway suppressor 1	COP9 signalosome subunit 7A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Protein Binding
	Biological Process	Protein Deneddylation JNK Cascade Protein Neddylation Regulation Of Protein Neddylation	Protein Deneddylation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172) Red blood cell count ( 32888494)
Interacting Genes		26 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CUL1 CUL2 CUL3 CUL5 ELOB IP6K1 ITPK1 OGT RBX1 SAP130 SENP8 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL	20 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 KRT19P3 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53
Entrez ID		2873	50813
HPRD ID		15991	16736
Ensembl ID		ENSG00000169727	ENSG00000111652
Uniprot IDs		A0A096LP07 A0A096LPJ3 A0A9L9PX62 A0A9L9PXT0 A8K070 C9JFE4 Q13098	Q9UBW8
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	4D10 4D18 4WSN
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Neddylation Protein Modification Process Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification COP9 Signalosome Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Removal Cullin-RING Ubiquitin Ligase Complex Protein Metabolic Process Protein K48-linked Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Protein Ubiquitination Regulation Of Protein Modification Process Cytosol G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Proteolysis DeNEDDylase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Nucleus Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Macromolecule Catabolic Process Catabolic Process Cell Cycle Phase Transition Protein Polyubiquitination Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Cul5-RING Ubiquitin Ligase Complex Ubiquitin-protein Transferase Activity Protein Catabolic Process Cul2-RING Ubiquitin Ligase Complex Negative Regulation Of TORC1 Signaling Regulation Of TOR Signaling Positive Regulation Of Epithelial Cell Apoptotic Process Cytoplasm Intrinsic Apoptotic Signaling Pathway VCB Complex Negative Regulation Of TOR Signaling	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Protein Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process PML Body Regulation Of Blood Vessel Endothelial Cell Migration Nucleus Cellular Response To Hypoxia DeNEDDylase Activity Cellular Response To Decreased Oxygen Levels Regulation Of Cellular Response To Stress Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Protein Phosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Phosphorylation Regulation Of Apoptotic Signaling Pathway Regulation Of Endothelial Cell Migration GTPase Inhibitor Activity Eukaryotic Translation Initiation Factor 3 Complex Type II Interferon-mediated Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Cellular Response To Angiotensin Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Response To Hypoxia Positive Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction By P53 Class Mediator Response To Angiotensin Nucleoplasm Negative Regulation Of Programmed Cell Death Cytoplasm Response To Decreased Oxygen Levels
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