PPP2R3B and PPP2R1B

Number of citations of the paper that reports this interaction (PubMedID 12370081)
36

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PPP2R3B	PPP2R1B
Description		protein phosphatase 2 regulatory subunit B''beta	protein phosphatase 2 scaffold subunit Abeta
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol Cilium	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol Membrane Raft Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Protein Phosphatase Regulator Activity Metal Ion Binding	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Protein Dephosphorylation Regulation Of Cell Cycle	Spindle Assembly Meiotic Sister Chromatid Cohesion, Centromeric Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red blood cell count ( 32888494)
Interacting Genes		11 interacting genes: CDC6 DUSP12 HGS NAA10 NOD2 PPP2CA PPP2R1A PPP2R1B SHANK3 TMEM14B UBC	42 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 JAK2 MCM3 OGT PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 UBC UNC5B
Entrez ID		28227	5519
HPRD ID		02276	04384
Ensembl ID		ENSG00000167393	ENSG00000137713
Uniprot IDs		Q9Y5P8	P30154
PDB IDs		4I5L 4I5N 4MEW
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein Serine/threonine Phosphatase Activity Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand INTAC Complex FAR/SIN/STRIPAK Complex Regulation Of Cell Cycle Process RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition T Cell Homeostasis Nuclear RNA Surveillance Homeostasis Of Number Of Cells Cytosol RNA Surveillance Protein Phosphatase Regulator Activity Sister Chromatid Cohesion Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity DNA-templated Transcription Elongation RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Glycine Secretion, Neurotransmission Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Homeostasis Lateral Plasma Membrane Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Leukocyte Homeostasis Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Organelle Assembly Positive Regulation Of Heme Biosynthetic Process Regulation Of Synaptic Transmission, Glycinergic Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Detection Of Peptidoglycan Guanylate Kinase-associated Protein Clustering Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Protein Tyrosine Phosphatase Activity Spindle Assembly Regulation Of Heme Biosynthetic Process	Protein Phosphatase Type 2A Complex Circadian Regulation Of Gene Expression Protein Phosphatase Regulator Activity Cytosol Rhythmic Process Circadian Rhythm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peroxiredoxin Activity Regulation Of Circadian Rhythm Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Sister Chromatid Cohesion Sister Chromatid Cohesion Cellular Response To Stress Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Removal Of Superoxide Radicals FAR/SIN/STRIPAK Complex Protein Phosphatase Activator Activity E-box Binding Positive Regulation Of Circadian Rhythm Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Schwann Cell Differentiation Response To Oxidative Stress Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Glucocorticoid Secretion Photoperiodism Regulation Of Programmed Cell Death Response To Reactive Oxygen Species Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Signaling Pathway Protein Phosphatase 2A Binding Thioredoxin-dependent Peroxiredoxin Activity Nucleotide Binding Cytoplasm Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction Negative Regulation Of Neuron Apoptotic Process
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