PPP2R3B and CDC6

Number of citations of the paper that reports this interaction (PMID 10629059)
24

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)
HPRD (in vivo, in vitro, two hybrid)

		PPP2R3B	CDC6
Gene Name		protein phosphatase 2, regulatory subunit B, beta	cell division cycle 6
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Protein Phosphatase Type 2A Regulator Activity	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Dephosphorylation Cell Cycle Arrest Regulation Of Catalytic Activity	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation
Pathways		E2F mediated regulation of DNA replication Cyclin D associated events in G1 G1/S Transition G1 Phase Mitotic G1-G1/S phases Inhibition of replication initiation of damaged DNA by RB1/E2F1 Cell Cycle, Mitotic	CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CDC6 DUSP12 PPP2CA PPP2R1A PPP2R1B	36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1
Entrez ID		28227	990
HPRD ID		02276	04022
Ensembl ID		ENSG00000167393	ENSG00000094804
Uniprot IDs		Q9Y5P8	Q99741
PDB IDs		4I5L 4I5N	2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Mitotic Nuclear Envelope Reassembly Regulation Of DNA Replication Nuclear Envelope Reassembly Regulation Of Kinase Activity Negative Regulation Of JAK-STAT Cascade Protein Dephosphorylation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Inactivation Of MAPK Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Dephosphorylation Regulation Of Phosphorus Metabolic Process Nuclear Envelope Organization Negative Regulation Of MAP Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of JAK-STAT Cascade Ceramide Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Mitotic Cell Cycle Process Nucleus Organization Regulation Of Protein Kinase Activity Mitotic Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Second-messenger-mediated Signaling Nuclear-transcribed MRNA Catabolic Process Peptidyl-serine Dephosphorylation Negative Regulation Of Cell Growth Negative Regulation Of MAPK Cascade Sphingolipid Metabolic Process MRNA Catabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity RNA Catabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Apoptotic Process Response To Fibroblast Growth Factor Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Peptidyl-tyrosine Phosphorylation Cell Cycle Process Negative Regulation Of Protein Kinase Activity Cell Death Death Membrane Lipid Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Kinase Activity	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process
Tagcloud ?			antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Difference) ?			antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Intersection) ?