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PPP2R3B and PPP2R1A
Number of citations of the paper that reports this interaction (PMID
18782753
)
60
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
HPRD
(in vitro, two hybrid)
PPP2R3B
PPP2R1A
Gene Name
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit A, alpha
Image
Gene Ontology Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Nucleus
Nucleoplasm
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Mitochondrion
Cytosol
Microtubule Cytoskeleton
Membrane
Extracellular Vesicular Exosome
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Calcium Ion Binding
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Antigen Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Protein Heterodimerization Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Protein Dephosphorylation
Cell Cycle Arrest
Regulation Of Catalytic Activity
G2/M Transition Of Mitotic Cell Cycle
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Inactivation Of MAPK Activity
Mitotic Cell Cycle
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Complex Assembly
Protein Dephosphorylation
Ceramide Metabolic Process
Apoptotic Process
Organelle Organization
Chromosome Segregation
Mitotic Nuclear Envelope Reassembly
RNA Splicing
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Organic Substance
Gene Expression
Second-messenger-mediated Signaling
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
Regulation Of Growth
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Regulation Of Cell Differentiation
Peptidyl-serine Dephosphorylation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
E2F mediated regulation of DNA replication
Cyclin D associated events in G1
G1/S Transition
G1 Phase
Mitotic G1-G1/S phases
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Cell Cycle, Mitotic
Signaling by FGFR in disease
Integration of energy metabolism
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
Toll Like Receptor TLR1:TLR2 Cascade
Glucose metabolism
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
MyD88 dependent cascade initiated on endosome
Glycogen storage diseases
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
Recruitment of mitotic centrosome proteins and complexes
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
S45 mutants of beta-catenin aren't phosphorylated
Spry regulation of FGF signaling
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
Platelet sensitization by LDL
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Adaptive Immune System
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
G2/M Transition
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
Cyclin A/B1 associated events during G2/M transition
Loss of Nlp from mitotic centrosomes
XAV939 inhibits tankyrase, stabilizing AXIN
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Innate Immune System
Nonsense-Mediated Decay (NMD)
E2F mediated regulation of DNA replication
ERKs are inactivated
G1 Phase
CTLA4 inhibitory signaling
Signaling by FGFR
Cyclin D associated events in G1
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Signaling by GPCR
Mitotic Prophase
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
Glycolysis
Regulation of PLK1 Activity at G2/M Transition
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
Myoclonic epilepsy of Lafora
Toll Like Receptor 9 (TLR9) Cascade
Initiation of Nuclear Envelope Reformation
ERK/MAPK targets
truncations of AMER1 destabilize the destruction complex
Negative regulation of FGFR signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
Toll Like Receptor 4 (TLR4) Cascade
Mitotic Metaphase and Anaphase
PP2A-mediated dephosphorylation of key metabolic factors
Mitotic Prometaphase
Organelle biogenesis and maintenance
Costimulation by the CD28 family
Toll Like Receptor 7/8 (TLR7/8) Cascade
Mitotic Anaphase
APC truncation mutants are not K63 polyubiquitinated
M Phase
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 cascade initiated on plasma membrane
DARPP-32 events
Nuclear Envelope Reassembly
Signalling by NGF
MAP kinase activation in TLR cascade
Assembly of the primary cilium
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Anchoring of the basal body to the plasma membrane
Cell Cycle, Mitotic
Loss of proteins required for interphase microtubule organization from the centrosome
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Centrosome maturation
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions
5 interactors:
CDC6
DUSP12
PPP2CA
PPP2R1A
PPP2R1B
39 interactors:
AIMP2
AKT1
ARIH2
CDK1
CSDC2
EEF2
GNA12
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
MAP3K7
MAPK6
MCM3
PARK7
PLA2G16
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP4C
PPP5C
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RAP1A
SGOL1
SGOL2
SLC6A2
SMAD2
SMAD3
STRN
STRN3
TAB1
TRADD
ZFYVE9
Entrez ID
28227
5518
HPRD ID
02276
16184
Ensembl ID
ENSG00000167393
Uniprot IDs
Q9Y5P8
A8K7B7
P30153
PDB IDs
4I5L
4I5N
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Mitotic Nuclear Envelope Reassembly
Regulation Of DNA Replication
Nuclear Envelope Reassembly
Regulation Of Kinase Activity
Negative Regulation Of JAK-STAT Cascade
Protein Dephosphorylation
Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Inactivation Of MAPK Activity
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Phosphorylation
Dephosphorylation
Regulation Of Phosphorus Metabolic Process
Nuclear Envelope Organization
Negative Regulation Of MAP Kinase Activity
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of JAK-STAT Cascade
Ceramide Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Mitotic Cell Cycle Process
Nucleus Organization
Regulation Of Protein Kinase Activity
Mitotic Cell Cycle
Negative Regulation Of Protein Serine/threonine Kinase Activity
Second-messenger-mediated Signaling
Nuclear-transcribed MRNA Catabolic Process
Peptidyl-serine Dephosphorylation
Negative Regulation Of Cell Growth
Negative Regulation Of MAPK Cascade
Sphingolipid Metabolic Process
MRNA Catabolic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Catalytic Activity
RNA Catabolic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Apoptotic Process
Response To Fibroblast Growth Factor
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Programmed Cell Death
Regulation Of Peptidyl-tyrosine Phosphorylation
Cell Cycle Process
Negative Regulation Of Protein Kinase Activity
Cell Death
Death
Membrane Lipid Metabolic Process
Regulation Of Protein Phosphorylation
Negative Regulation Of Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Ras Protein Signal Transduction
Signaling
Intracellular Signal Transduction
Signal Transduction
Cell Communication
Positive Regulation Of Cellular Metabolic Process
SMAD Protein Complex Assembly
Mitotic Cell Cycle
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Signaling
Cellular Response To Stimulus
Cell Cycle Process
Response To Organic Substance
Cell Cycle
Mitotic Cell Cycle Process
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Regulation Of Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Complex Assembly
Regulation Of Protein Metabolic Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Cellular Process
Positive Regulation Of Metabolic Process
Response To Organic Cyclic Compound
Positive Regulation Of Protein Kinase Activity
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Protein Modification Process
Response To Transforming Growth Factor Beta
Positive Regulation Of Kinase Activity
Negative Regulation Of Signaling
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Signal Transduction
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Hydrogen Peroxide Metabolic Process
Programmed Cell Death
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Regulation Of Phosphorylation
Regulation Of Kinase Activity
Regulation Of Protein Localization
Toll-like Receptor Signaling Pathway
Tagcloud
?
arid1a
carcinomas
ccc
concurrent
constitute
ctnnb1
endometrial
endometrioid
endometrium
hepatocyte
hnf1beta
immunophenotype
mismatch
morphologically
mutated
napsin
oestrogen
oncogenesis
pole
predominance
prototypical
pten
pure
rigorously
serous
tp53
tumours
twelve
underscore
Tagcloud (Difference)
?
arid1a
carcinomas
ccc
concurrent
constitute
ctnnb1
endometrial
endometrioid
endometrium
hepatocyte
hnf1beta
immunophenotype
mismatch
morphologically
mutated
napsin
oestrogen
oncogenesis
pole
predominance
prototypical
pten
pure
rigorously
serous
tp53
tumours
twelve
underscore
Tagcloud (Intersection)
?