GOLGB1 and PFN2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		GOLGB1	PFN2
Gene Name		golgin B1	profilin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Stack Cis-Golgi Network Membrane Integral Component Of Membrane	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Golgi Organization	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways			Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ACBD3 BRMS1 CAV2 ITSN2 KIAA0368 KIAA1377 MAPK7 NDUFA1 PFN2 SKIL SLC2A3 SREBF2 UBE2I USO1 VTI1B	31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		2804	5217
HPRD ID		03933	01451
Ensembl ID		ENSG00000173230	ENSG00000070087
Uniprot IDs		F1T0J2 Q14789	G5E9Q6 P35080
PDB IDs			1D1J
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Cellular Response To Laminar Fluid Shear Stress Vesicle Fusion With Golgi Apparatus Organelle Fusion Vesicle Docking Membrane Docking Cellular Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Membrane Fusion Response To Fluid Shear Stress Vesicle Organization Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Golgi Vesicle Docking Negative Regulation Of CAMP Catabolic Process Organelle Organization ER To Golgi Vesicle-mediated Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Anoikis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cholesterol Efflux Skeletal Muscle Tissue Development Negative Regulation Of Ruffle Assembly Skeletal Muscle Organ Development Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Golgi To Vacuole Transport Negative Regulation Of Heterotypic Cell-cell Adhesion Caveola Assembly Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Transforming Growth Factor Beta Positive Regulation Of Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cholesterol Transport Membrane Raft Assembly	Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly
Tagcloud ?			actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?			actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?