GLI1 and WDR77

Number of citations of the paper that reports this interaction (PubMedID 30675521)
55

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		GLI1	WDR77
Description		GLI family zinc finger 1	WD repeat domain 77
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Axoneme Ciliary Basal Body Ciliary Tip Ciliary Base GLI-SUFU Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cul4B-RING E3 Ubiquitin Ligase Complex Methylosome Transferase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Microtubule Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Methyl-CpG Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Spermatid Development Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Anatomical Structure Morphogenesis Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Cerebellar Cortex Morphogenesis Pituitary Gland Development Cell Differentiation Lung Development Positive Regulation Of Cell Migration Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation	Protein Polyubiquitination Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Oocyte Axis Specification Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription	snRNP Assembly RMTs methylate histone arginines
Drugs
Diseases
GWAS
Interacting Genes		22 interacting genes: AQP1 CATSPER1 CCT2 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT1 PRMT5 RAI1 RUNX3 STK36 SUFU TAF9 TRIM42 WDR77 XBP1 ZIC1 ZIC2	46 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 EIF4A1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PDCD4 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 UBC YWHAB YWHAQ ZMYND19 ZNF207
Entrez ID		2735	79084
HPRD ID		01311	14387
Ensembl ID		ENSG00000111087	ENSG00000116455
Uniprot IDs		B4DNF7 P08151	A0A024R0H7 Q9BQA1
PDB IDs		2GLI 4BLB 4KMD 5OM0 7T91	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Methylosome Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smoothened Signaling Pathway Methyl-CpG Binding Protein Serine/threonine/tyrosine Kinase Activity Protein Localization To Lipid Droplet Positive Regulation Of Metabolic Process Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Splicing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Protein Transport Developmental Process Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Nucleoplasm Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Protein Phosphorylation Protein Metabolic Process Protein Serine Kinase Activity Cellular Response To Glucose Stimulus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Import Into Nucleus TORC1 Signaling Regulation Of Gene Expression Regulation Of RNA Splicing Negative Regulation Of TORC1 Signaling Nucleotide-activated Protein Kinase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytoplasm Phosphorylation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Carbohydrate Stimulus Negative Regulation Of Developmental Process Protein Serine/threonine Kinase Activity	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process Methylosome RNA Processing RNA Metabolic Process Spliceosomal Complex Assembly PICln-Sm Protein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Assembly Spliceosomal SnRNP Assembly U2 SnRNP Protein-RNA Complex Assembly Nucleic Acid Metabolic Process U2-type Spliceosomal Complex RNA Binding 7-methylguanosine Cap Hypermethylation U2-type Catalytic Step 2 Spliceosome U2-type Precatalytic Spliceosome Nucleoplasm U1 SnRNP Nucleus U4 SnRNP U12-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Precatalytic Spliceosome U5 SnRNP U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process U7 SnRNP Ribonucleoprotein Complex MRNA Binding Macromolecule Methylation Methylation RNA Methylation Commitment Complex Protein-containing Complex Assembly Nucleic Acid Binding Protein-containing Complex Organization RNA Modification CGMP-dependent Protein Kinase Activity MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Telomerase Holoenzyme Complex Histone Pre-mRNA DCP Binding
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