GLI1 and SUFU

Number of citations of the paper that reports this interaction (PMID 10559945)
98

Data Source:
HPRD (in vivo, in vitro)

		GLI1	SUFU
Gene Name		GLI family zinc finger 1	suppressor of fused homolog (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Primary Cilium Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm Cytosol Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	DNA Binding Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Transcription Corepressor Activity Signal Transducer Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding
	Biological Process	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Notochord Regression Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Neural Tube Closure Heart Looping Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organismal Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Negative Regulation Of Transcription Factor Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI proteins bind promoters of Hh responsive genes to promote transcription	Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		12 interactors: CDK4 DYRK1A FEM1B GCC1 PRKAA2 RAI1 STK36 SUFU TRIM42 XBP1 ZIC1 ZIC2	26 interactors: BTRC GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF747 ZNF764
Entrez ID		2735	51684
HPRD ID		01311	06124
Ensembl ID		ENSG00000111087	ENSG00000107882
Uniprot IDs		B4DNF7 F5H6H8 P08151	Q9UMX1
PDB IDs		2GLI	1M1L
Enriched GO Terms of Interacting Partners?		System Development Rhythmic Process Regulation Of Smoothened Signaling Pathway Fatty Acid Homeostasis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Epithelial Cell Maturation Circadian Rhythm Regulation Of Protein Import Into Nucleus Cellular Response To Glucose Starvation Regulation Of Signal Transduction Developmental Process Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Organ Development Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Autophagy Regulation Of Signaling Regulation Of RNA Metabolic Process Anion Homeostasis Regulation Of Intracellular Protein Transport Positive Regulation Of Metabolic Process Nervous System Development Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of TOR Signaling Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Serotonin Secretion, Neurotransmission Response To Insulin-like Growth Factor Stimulus Ammonium Transport Central Nervous System Development Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Cell Differentiation Involved In Salivary Gland Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Neural Tube Closure Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription	RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Notochord Regression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Mammary Gland Morphogenesis Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Tube Morphogenesis Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Gland Development Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organ Formation Proximal/distal Pattern Formation Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Pituitary Gland Development Gland Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Mammary Gland Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Tagcloud ?		alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss	beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Difference) ?		alp biogenesis coactivators colia cyclopamine esc escs hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss	beta1 blots cck colorectal constructed counting enhances ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Intersection) ?		gli1 hedgehog hh