GLI1 and RAI1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		GLI1	RAI1
Description		GLI family zinc finger 1	retinoic acid induced 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Axoneme Ciliary Basal Body Ciliary Tip Ciliary Base GLI-SUFU Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Microtubule Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Spermatid Development Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Anatomical Structure Morphogenesis Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Cerebellar Cortex Morphogenesis Pituitary Gland Development Cell Differentiation Lung Development Positive Regulation Of Cell Migration Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of DNA-templated Transcription Rhythmic Process
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription	Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs
Diseases			Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS			A body shape index ( 34021172) Body mass index ( 28892062) Caffeine consumption from coffee ( 33287642) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Glycated hemoglobin levels ( 34059833) Hip circumference ( 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 27863252) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 29483656 28991256 25056061) Type 2 diabetes ( 30054458 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		22 interacting genes: AQP1 CATSPER1 CCT2 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT1 PRMT5 RAI1 RUNX3 STK36 SUFU TAF9 TRIM42 WDR77 XBP1 ZIC1 ZIC2	17 interacting genes: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TET2 TOPBP1 TTR ZNF496
Entrez ID		2735	10743
HPRD ID		01311	07406
Ensembl ID		ENSG00000111087	ENSG00000108557
Uniprot IDs		B4DNF7 P08151	Q7Z5J4
PDB IDs		2GLI 4BLB 4KMD 5OM0 7T91
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Methylosome Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smoothened Signaling Pathway Methyl-CpG Binding Protein Serine/threonine/tyrosine Kinase Activity Protein Localization To Lipid Droplet Positive Regulation Of Metabolic Process Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Splicing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Protein Transport Developmental Process Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Nucleoplasm Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Protein Phosphorylation Protein Metabolic Process Protein Serine Kinase Activity Cellular Response To Glucose Stimulus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Import Into Nucleus TORC1 Signaling Regulation Of Gene Expression Regulation Of RNA Splicing Negative Regulation Of TORC1 Signaling Nucleotide-activated Protein Kinase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytoplasm Phosphorylation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Carbohydrate Stimulus Negative Regulation Of Developmental Process Protein Serine/threonine Kinase Activity	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II ER Overload Response RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Signaling Pathway Megakaryocyte Differentiation Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Nucleoplasm Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Growth Intracellular Signaling Cassette Regeneration Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Response To Ionizing Radiation Regulation Of JNK Cascade Positive Regulation Of Biosynthetic Process Mitotic G2 DNA Damage Checkpoint Signaling Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Developmental Process ER-nucleus Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
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