GLI1 and STK36

Number of citations of the paper that reports this interaction (PMID 10806483)
26

Data Source:
HPRD (in vivo)

		GLI1	STK36
Gene Name		GLI family zinc finger 1	serine/threonine kinase 36
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Primary Cilium Ciliary Tip Ciliary Base	Nucleus Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding
	Biological Process	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Notochord Regression Negative Regulation Of Canonical Wnt Signaling Pathway	Epithelial Cilium Movement Protein Phosphorylation Positive Regulation Of Hh Target Transcription Factor Activity Brain Development Post-embryonic Development Cilium Assembly Positive Regulation Of Smoothened Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 22959728)
Protein-Protein Interactions		12 interactors: CDK4 DYRK1A FEM1B GCC1 PRKAA2 RAI1 STK36 SUFU TRIM42 XBP1 ZIC1 ZIC2	9 interactors: CDK5RAP2 CDK9 FRMPD4 GLI1 GLI2 GLI3 MAST2 MID1 SUFU
Entrez ID		2735	27148
HPRD ID		01311	09631
Ensembl ID		ENSG00000111087	ENSG00000163482
Uniprot IDs		B4DNF7 F5H6H8 P08151	Q9NRP7
PDB IDs		2GLI
Enriched GO Terms of Interacting Partners?		System Development Rhythmic Process Regulation Of Smoothened Signaling Pathway Fatty Acid Homeostasis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Epithelial Cell Maturation Circadian Rhythm Regulation Of Protein Import Into Nucleus Cellular Response To Glucose Starvation Regulation Of Signal Transduction Developmental Process Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Organ Development Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Autophagy Regulation Of Signaling Regulation Of RNA Metabolic Process Anion Homeostasis Regulation Of Intracellular Protein Transport Positive Regulation Of Metabolic Process Nervous System Development Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of TOR Signaling Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Serotonin Secretion, Neurotransmission Response To Insulin-like Growth Factor Stimulus Ammonium Transport Central Nervous System Development Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Cell Differentiation Involved In Salivary Gland Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Neural Tube Closure Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription	Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Smoothened Signaling Pathway Ventral Spinal Cord Interneuron Differentiation Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Notochord Regression Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Spinal Cord Patterning Pattern Specification Process Spinal Cord Motor Neuron Differentiation Proximal/distal Pattern Formation Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Positive Regulation Of Neural Precursor Cell Proliferation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Digestive Tract Morphogenesis Neuron Fate Commitment Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Embryonic Organ Morphogenesis Hindgut Morphogenesis Notochord Morphogenesis Cell Fate Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Hindgut Development Regulation Of Neural Precursor Cell Proliferation Spinal Cord Development Regulation Of DNA Replication Tube Morphogenesis Central Nervous System Development Anatomical Structure Regression Digestive Tract Development Digestive System Development Embryonic Organ Development Notochord Development Neural Tube Development Positive Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Central Nervous System Neuron Differentiation Negative Regulation Of Smoothened Signaling Pathway Dorsal/ventral Neural Tube Patterning Tube Development Lung Development
Tagcloud ?		alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss
Tagcloud (Difference) ?		alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss
Tagcloud (Intersection) ?