GLI1 and ZIC2

Number of citations of the paper that reports this interaction (PubMedID 11238441)
0

Data Source:
HPRD (in vitro)

		GLI1	ZIC2
Description		GLI family zinc finger 1	Zic family zinc finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Axoneme Ciliary Basal Body Ciliary Tip Ciliary Base GLI-SUFU Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Microtubule Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Spermatid Development Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Anatomical Structure Morphogenesis Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Cerebellar Cortex Morphogenesis Pituitary Gland Development Cell Differentiation Lung Development Positive Regulation Of Cell Migration Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation	Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Brain Development Visual Perception Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of DNA-binding Transcription Factor Activity
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription	Formation of the anterior neural plate
Drugs
Diseases			Holoprosencephaly (HPE)
GWAS			Hyperopia ( 25233373) Myopia ( 27182965) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		22 interacting genes: AQP1 CATSPER1 CCT2 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT1 PRMT5 RAI1 RUNX3 STK36 SUFU TAF9 TRIM42 WDR77 XBP1 ZIC1 ZIC2	3 interacting genes: GLI1 GLI2 GLI3
Entrez ID		2735	7546
HPRD ID		01311	04353
Ensembl ID		ENSG00000111087	ENSG00000043355
Uniprot IDs		B4DNF7 P08151	O95409
PDB IDs		2GLI 4BLB 4KMD 5OM0 7T91
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Methylosome Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smoothened Signaling Pathway Methyl-CpG Binding Protein Serine/threonine/tyrosine Kinase Activity Protein Localization To Lipid Droplet Positive Regulation Of Metabolic Process Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Splicing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Protein Transport Developmental Process Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Nucleoplasm Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Protein Phosphorylation Protein Metabolic Process Protein Serine Kinase Activity Cellular Response To Glucose Stimulus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Import Into Nucleus TORC1 Signaling Regulation Of Gene Expression Regulation Of RNA Splicing Negative Regulation Of TORC1 Signaling Nucleotide-activated Protein Kinase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytoplasm Phosphorylation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Carbohydrate Stimulus Negative Regulation Of Developmental Process Protein Serine/threonine Kinase Activity	GLI-SUFU Complex Proximal/distal Pattern Formation Ciliary Tip Ciliary Base Dorsal/ventral Pattern Formation Ventral Midline Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Hindgut Morphogenesis Lung Development Cerebellar Cortex Morphogenesis Osteoblast Differentiation Double-stranded DNA Binding Spinal Cord Dorsal/ventral Patterning Embryonic Digestive Tract Development Gland Development Regionalization Tube Morphogenesis Pituitary Gland Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Pattern Specification Process Mammary Gland Development Positive Regulation Of DNA Replication Sequence-specific DNA Binding Digestive Tract Development Cilium Odontogenesis Of Dentin-containing Tooth Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Odontogenesis Regulation Of DNA Replication Notochord Regression Axoneme Positive Regulation Of T Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Lateral Semicircular Canal Development Sagittal Suture Morphogenesis Lambdoid Suture Morphogenesis Lateral Ganglionic Eminence Cell Proliferation Anterior Semicircular Canal Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Osteoblast Differentiation Morphogenesis Of A Branching Epithelium DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Morphogenesis Of A Branching Structure Embryonic Organ Development Kidney Development Negative Regulation Of Wnt Signaling Pathway
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