GLI1 and FEM1B

Number of citations of the paper that reports this interaction (PMID 24076122)
0

Data Source:
BioGRID (pull down)

		GLI1	FEM1B
Gene Name		GLI family zinc finger 1	fem-1 homolog b (C. elegans)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Primary Cilium Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Death Receptor Binding Protein Binding
	Biological Process	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Notochord Regression Negative Regulation Of Canonical Wnt Signaling Pathway	Apoptotic Process Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS			Major depressive disorder ( 23377640)
Protein-Protein Interactions		12 interactors: CDK4 DYRK1A FEM1B GCC1 PRKAA2 RAI1 STK36 SUFU TRIM42 XBP1 ZIC1 ZIC2	8 interactors: APAF1 FAS GLI1 HIF1AN KIAA0319 NKX3-1 PPM1F RAD9A
Entrez ID		2735	10116
HPRD ID		01311	16889
Ensembl ID		ENSG00000111087
Uniprot IDs		B4DNF7 F5H6H8 P08151	Q9UK73
PDB IDs		2GLI
Enriched GO Terms of Interacting Partners?		System Development Rhythmic Process Regulation Of Smoothened Signaling Pathway Fatty Acid Homeostasis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Epithelial Cell Maturation Circadian Rhythm Regulation Of Protein Import Into Nucleus Cellular Response To Glucose Starvation Regulation Of Signal Transduction Developmental Process Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Organ Development Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Autophagy Regulation Of Signaling Regulation Of RNA Metabolic Process Anion Homeostasis Regulation Of Intracellular Protein Transport Positive Regulation Of Metabolic Process Nervous System Development Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of TOR Signaling Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Serotonin Secretion, Neurotransmission Response To Insulin-like Growth Factor Stimulus Ammonium Transport Central Nervous System Development Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Cell Differentiation Involved In Salivary Gland Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Neural Tube Closure Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription	Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Zymogen Activation Cellular Response To Oxygen Levels Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Regulation Of Proteolysis Regulation Of Apoptotic Process Protein Processing Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Drug Neuron Apoptotic Process Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Neuron Death Positive Regulation Of Hydrolase Activity Positive Regulation Of Response To DNA Damage Stimulus Cell Death Death Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Tube Morphogenesis Peptidyl-histidine Hydroxylation Response To G1 DNA Damage Checkpoint Signaling Peptidyl-asparagine Hydroxylation Positive Regulation Of Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Peptidyl-aspartic Acid Hydroxylation Motor Neuron Apoptotic Process Positive Regulation Of Androgen Secretion Cellular Response To Stimulus Regulation Of Response To DNA Damage Stimulus
Tagcloud ?		alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss
Tagcloud (Difference) ?		alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss
Tagcloud (Intersection) ?