GLI1 and XBP1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		GLI1	XBP1
Gene Name		GLI family zinc finger 1	X-box binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Primary Cilium Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	DNA Binding Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Transcription Factor Binding Enhancer Sequence-specific DNA Binding Protease Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Notochord Regression Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Liver Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Immunoglobulin Production Transcription From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Phosphatidylinositol 3-kinase Signaling Cell Growth Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Positive Regulation Of Histone Methylation Regulation Of Protein Stability Protein Destabilization Cellular Response To Nutrient Positive Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cellular Triglyceride Homeostasis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Glucose Starvation Response To Drug Cholesterol Homeostasis Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Positive Regulation Of Immunoglobulin Secretion Response To Electrical Stimulus Fatty Acid Homeostasis Sterol Homeostasis Serotonin Secretion, Neurotransmission Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Antibiotic Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-6 Secretion
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS			Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		12 interactors: CDK4 DYRK1A FEM1B GCC1 PRKAA2 RAI1 STK36 SUFU TRIM42 XBP1 ZIC1 ZIC2	19 interactors: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1F0 H1FX HDGF NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I ZNF440 ZNF580
Entrez ID		2735	7494
HPRD ID		01311	01908
Ensembl ID		ENSG00000111087	ENSG00000100219
Uniprot IDs		B4DNF7 F5H6H8 P08151	P17861
PDB IDs		2GLI
Enriched GO Terms of Interacting Partners?		System Development Rhythmic Process Regulation Of Smoothened Signaling Pathway Fatty Acid Homeostasis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Epithelial Cell Maturation Circadian Rhythm Regulation Of Protein Import Into Nucleus Cellular Response To Glucose Starvation Regulation Of Signal Transduction Developmental Process Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Organ Development Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Autophagy Regulation Of Signaling Regulation Of RNA Metabolic Process Anion Homeostasis Regulation Of Intracellular Protein Transport Positive Regulation Of Metabolic Process Nervous System Development Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of TOR Signaling Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Serotonin Secretion, Neurotransmission Response To Insulin-like Growth Factor Stimulus Ammonium Transport Central Nervous System Development Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Cell Differentiation Involved In Salivary Gland Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Neural Tube Closure Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Estrogen Receptor Signaling Pathway Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Regulation Of Cellular Process Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of SUMO Transferase Activity Positive Regulation Of Nuclease Activity Regulation Of DNA-templated Transcription In Response To Stress Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Organization Cellular Response To Organic Substance Notochord Regression
Tagcloud ?		alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss	alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced stx stx2 toxigenic toxins transcripts untreated uremic
Tagcloud (Difference) ?		alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss	alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced stx stx2 toxigenic toxins transcripts untreated uremic
Tagcloud (Intersection) ?