GLI1

Gene Name		GLI family zinc finger 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	DNA Binding Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Notochord Regression Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS
Protein-protein Interactions		12 interactors: CDK4 DYRK1A FEM1B GCC1 PRKAA2 RAI1 STK36 SUFU TRIM42 XBP1 ZIC1 ZIC2
Entrez ID		2735
HPRD ID		01311
Ensembl ID		ENSG00000111087
Uniprot IDs		B4DNF7 F5H6H8 P08151
PDB IDs		2GLI
Enriched GO Terms of Interacting Partners?		System Development Rhythmic Process Regulation Of Smoothened Signaling Pathway Fatty Acid Homeostasis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Epithelial Cell Maturation Circadian Rhythm Regulation Of Protein Import Into Nucleus Cellular Response To Glucose Starvation Regulation Of Signal Transduction Developmental Process Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Organ Development Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Autophagy Regulation Of Signaling Regulation Of RNA Metabolic Process Anion Homeostasis Regulation Of Intracellular Protein Transport Positive Regulation Of Metabolic Process Nervous System Development Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of TOR Signaling Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Serotonin Secretion, Neurotransmission Response To Insulin-like Growth Factor Stimulus Ammonium Transport Central Nervous System Development Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Cell Differentiation Involved In Salivary Gland Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Neural Tube Closure Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss