CHMP2A and USP8

Number of citations of the paper that reports this interaction (PMID 19302785)
6

Data Source:
BioGRID (pull down)

		CHMP2A	USP8
Gene Name		charged multivesicular body protein 2A	ubiquitin specific peptidase 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Late Endosome Membrane Extracellular Vesicular Exosome	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Process Endosomal Transport Viral Life Cycle Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization Regulation Of Viral Process Negative Regulation Of Cell Death Membrane Organization Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CHMP3 DOCK8 E2F4 EIF2B5 MITD1 NOL4 STAMBP TGFB3 USP54 USP8 VPS4A VPS4B	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		27243	9101
HPRD ID		12520	04405
Ensembl ID		ENSG00000130724	ENSG00000138592
Uniprot IDs		O43633	P40818
PDB IDs			1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Cell Division Cytokinesis Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cytokinesis Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Cycle Process Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Release From Host Cell Viral Budding Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cell Cycle Regulation Of Viral Release From Host Cell Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic Metaphase Plate Congression Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Endosome Organization Metaphase Plate Congression Endosomal Transport Protein Catabolic Process Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Cell Division Regulation Of Centrosome Cycle Proteolysis Positive Regulation Of Exocytosis Positive Regulation Of Secretion Cellular Macromolecule Catabolic Process Negative Regulation Of Exosomal Secretion Memory T Cell Proliferation Positive Regulation Of Centriole Elongation Positive Regulation Of Viral Process Mitotic Sister Chromatid Segregation Membrane Budding Sister Chromatid Segregation Negative Regulation Of Cell Death Positive Regulation Of Centriole Replication Detection Of Hypoxia Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Uterine Wall Breakdown Ovulation Cycle Process Vacuole Organization Protein Deubiquitination	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?			ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?			ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?