CHMP2A and CHMP3

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical, cross-linking study, affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		CHMP2A	CHMP3
Description		charged multivesicular body protein 2A	charged multivesicular body protein 3
Image
GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore Chromatin ESCRT III Complex Nucleus Nuclear Envelope Nuclear Pore Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Membrane Coat Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Early Endosome Late Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding Phosphatidylcholine Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylcholine Binding Identical Protein Binding Molecular Function Inhibitor Activity Ubiquitin-specific Protease Binding
	Biological Process	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Membrane Invagination Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Protein Polymerization Protein Homooligomerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation ESCRT III Complex Disassembly	Plasma Membrane Repair Autophagy Apoptotic Process Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Suppression Of Viral Release By Host Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Regulation Of Endosome Size Protein Polymerization Cell Division Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion Regulation Of Early Endosome To Late Endosome Transport
Pathways		Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Adult body size ( 32376654) Glomerular filtration rate in chronic kidney disease ( 26420894) Nicotine dependence symptom count ( 25555482)
Interacting Genes		14 interacting genes: CHMP3 DOCK8 E2F4 EIF2B5 MITD1 NOL4 SNCA STAMBP TGFB3 UFD1 USP54 USP8 VPS4A VPS4B	14 interacting genes: APP CHMP2A CHMP2B CHMP4A CHMP4B FBXO7 HSPA13 IGFBP7 RAB11A SMAD1 SMAD5 STAMBP TNPO3 VAV2
Entrez ID		27243	51652
HPRD ID		12520	15650
Ensembl ID		ENSG00000130724	ENSG00000115561
Uniprot IDs		M0R1T5 O43633	Q9Y3E7
PDB IDs		7ZCG 7ZCH	2GD5 2XZE 3FRT 3FRV 7ZCG 7ZCH
Enriched GO Terms of Interacting Partners?		Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Cytokinetic Process Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane K63-linked Deubiquitinase Activity Late Endosome To Lysosome Transport Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Regulation Of Exosomal Secretion Midbody Endosome Organization Nuclear Membrane Reassembly Cytoskeleton-dependent Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Viral Process Late Endosome Membrane Positive Regulation Of Secretion Biological Process Involved In Interaction With Host Endosome To Lysosome Transport Metaphase Chromosome Alignment Membrane Assembly ESCRT III Complex Disassembly ESCRT Complex Disassembly Mitotic Cytokinesis ATPase Complex Regulation Of Exocytosis Regulation Of Secretion Chromosome Localization Positive Regulation Of Exocytosis Positive Regulation Of Exosomal Secretion Nuclear Pore Protein Domain Specific Binding Cysteine-type Deubiquitinase Activity Nucleus Organization Protein Deubiquitination	Kinetochore Microtubule Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Multivesicular Body Mitotic Metaphase Chromosome Alignment Viral Budding From Plasma Membrane Lysosomal Membrane Organization Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Chromosome Localization Mitotic Cytokinetic Process Endosome Organization Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Membrane Assembly Nuclear Pore Nucleus Organization Endosome Vesicle Fusion Organelle Membrane Fusion Regulation Of Organelle Assembly Endosomal Transport Membrane Coat Osteoblast Fate Commitment Plasma Membrane Organization Lysosomal Transport Cytosol Autophagy Organelle Fusion
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