GLS2 and SNTA1

Number of citations of the paper that reports this interaction (PubMedID 11163757)
0

Data Source:
HPRD (in vivo)

		GLS2	SNTA1
Description		glutaminase 2	syntrophin alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction
	Molecular Function	Glutaminase Activity Protein Binding Hydrolase Activity	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Metabolic Process L-glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Glutamic acid
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Adverse response to drug ( 30420678) Axial length ( 24144296) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Lipoprotein (a) levels ( 33730874) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 23093944 31636271) Serum metabolite levels (CMS) ( 31636271)	HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)
Interacting Genes		14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR PAG1 PATJ RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1	76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6
Entrez ID		27165	6640
HPRD ID		05901	03009
Ensembl ID		ENSG00000135423	ENSG00000101400
Uniprot IDs		A0A087X004 Q9UI32	B3KTR0 Q13424
PDB IDs		4BQM 5U0K 8SZL 8T0Z
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Ionotropic Glutamate Receptor Binding GMP Kinase Activity Receptor Localization To Synapse Receptor Clustering GDP Metabolic Process Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Synaptic Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein Localization To Cell Junction Kinase Binding GMP Metabolic Process Postsynaptic Density Membrane Adherens Junction Cell Junction Nucleoside Monophosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Juxtaparanode Region Of Axon Nucleoside Diphosphate Metabolic Process Basolateral Plasma Membrane Plasma Membrane Cellular Response To Potassium Ion Localization Within Membrane Purine Ribonucleotide Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Protein Localization To Membrane Chemical Synaptic Transmission Response To Potassium Ion Bicellular Tight Junction Neuron Projection Trans-synaptic Signaling Synaptic Signaling Purine Nucleotide Metabolic Process AMPA Glutamate Receptor Complex Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Nucleotide Metabolic Process Regulation Of Sodium Ion Transmembrane Transport Intracellular Signal Transduction Protein Kinase Binding Purine-containing Compound Metabolic Process Cell-cell Junction Cell Adhesion P2Y1 Nucleotide Receptor Binding Hydroxypyruvate Reductase [NAD(P)H] Activity	Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process
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