GLS2 and PATJ

Number of citations of the paper that reports this interaction (PubMedID 16637659)
54

Data Source:
HPRD (in vitro)

		GLS2	PATJ
Description		glutaminase 2	PATJ crumbs cell polarity complex component
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	Glutaminase Activity Protein Binding Hydrolase Activity	Protein Binding
	Biological Process	Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Metabolic Process L-glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs		Glutamic acid
Diseases
GWAS		Adverse response to drug ( 30420678) Axial length ( 24144296) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Lipoprotein (a) levels ( 33730874) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 23093944 31636271) Serum metabolite levels (CMS) ( 31636271)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)
Interacting Genes		14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR PAG1 PATJ RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1	35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3
Entrez ID		27165	10207
HPRD ID		05901	04434
Ensembl ID		ENSG00000135423	ENSG00000132849
Uniprot IDs		A0A087X004 Q9UI32	A0A2R8Y549 Q8NI35
PDB IDs		4BQM 5U0K 8SZL 8T0Z	1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Ionotropic Glutamate Receptor Binding GMP Kinase Activity Receptor Localization To Synapse Receptor Clustering GDP Metabolic Process Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Synaptic Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein Localization To Cell Junction Kinase Binding GMP Metabolic Process Postsynaptic Density Membrane Adherens Junction Cell Junction Nucleoside Monophosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Juxtaparanode Region Of Axon Nucleoside Diphosphate Metabolic Process Basolateral Plasma Membrane Plasma Membrane Cellular Response To Potassium Ion Localization Within Membrane Purine Ribonucleotide Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Protein Localization To Membrane Chemical Synaptic Transmission Response To Potassium Ion Bicellular Tight Junction Neuron Projection Trans-synaptic Signaling Synaptic Signaling Purine Nucleotide Metabolic Process AMPA Glutamate Receptor Complex Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Nucleotide Metabolic Process Regulation Of Sodium Ion Transmembrane Transport Intracellular Signal Transduction Protein Kinase Binding Purine-containing Compound Metabolic Process Cell-cell Junction Cell Adhesion P2Y1 Nucleotide Receptor Binding Hydroxypyruvate Reductase [NAD(P)H] Activity	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation
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