GLS2 and TAX1BP3

Number of citations of the paper that reports this interaction (PMID 11163757)
12

Data Source:
HPRD (two hybrid, in vitro)

		GLS2	TAX1BP3
Gene Name		glutaminase 2 (liver, mitochondrial)	Tax1 (human T-cell leukemia virus type I) binding protein 3
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Glutaminase Activity Protein Binding	Protein Binding Beta-catenin Binding Protein C-terminus Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamine Metabolic Process Synaptic Transmission Neurotransmitter Secretion Cellular Amino Acid Biosynthetic Process Glutamate Secretion Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process	Rho Protein Signal Transduction Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Activation Of Cdc42 GTPase Activity Negative Regulation Of Protein Localization To Cell Surface
Pathways		Neurotransmitter Release Cycle Amino acid synthesis and interconversion (transamination) Glutamate Neurotransmitter Release Cycle Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037)
Protein-Protein Interactions		11 interactors: CASK DLG1 DLG2 DLG3 DLG4 GRHPR INADL PAG1 RGS3 SNTA1 TAX1BP3	14 interactors: ARNT2 CDK5RAP3 CNTN2 CTNNB1 DTX1 GATA1 GLS GLS2 PLK4 RNF183 RTKN STAU1 TCEA2 TRIM29
Entrez ID		27165	30851
HPRD ID		05901	18160
Ensembl ID		ENSG00000135423	ENSG00000213977
Uniprot IDs		Q9UI32	O14907
PDB IDs		4BQM	2KG2 2L4S 2L4T 2VZ5 3GJ9 3SFJ 4E3B
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Synaptic Transmission Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell Proliferation Regulation Of Membrane Potential Tight Junction Assembly Small Molecule Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Membrane Organization Negative Regulation Of Dephosphorylation Regulation Of Vasoconstriction By Circulating Norepinephrine Apical Junction Assembly Cell-cell Signaling Axon Guidance Negative Regulation Of T Cell Activation Phosphorylation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phosphatase Activity Negative Regulation Of Homotypic Cell-cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Metabolic Process Axonogenesis Regulation Of Dephosphorylation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production Negative Regulation Of Leukocyte Activation Chemotaxis Regulation Of Cell Adhesion	Glutamate Secretion Glutamine Metabolic Process Regulation Of Glycoprotein Biosynthetic Process Glial Cell Differentiation In Utero Embryonic Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Gliogenesis Regulation Of Neurogenesis Centrosome Cycle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Neurogenesis Acid Secretion Establishment Of Protein Localization To Juxtaparanode Region Of Axon Brain Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Cell Development Head Development Regulation Of Glial Cell Differentiation Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Development Positive Regulation Of Gene Expression RNA Biosynthetic Process Dicarboxylic Acid Transport Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Cell-cell Signaling Basophil Differentiation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Centriole Replication Positive Regulation Of Adenosine Receptor Signaling Pathway Schwann Cell Proliferation Eosinophil Fate Commitment Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Telencephalon Cell Migration Biosynthetic Process Centrosome Organization Forebrain Cell Migration Regulation Of Gliogenesis Central Nervous System Development Neurotransmitter Secretion Microtubule Cytoskeleton Organization Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Eosinophil Differentiation Clustering Of Voltage-gated Potassium Channels
Tagcloud ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces	anxa6 art atomic benchmarked biologically calu cdc42 differentially distinctive experimentally exploit feasibility identity integrating modeled modeling opposite pair pairs pipeline predictions proteomic ptbp1 solved splice splicing tasser translated variants
Tagcloud (Difference) ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces	anxa6 art atomic benchmarked biologically calu cdc42 differentially distinctive experimentally exploit feasibility identity integrating modeled modeling opposite pair pairs pipeline predictions proteomic ptbp1 solved splice splicing tasser translated variants
Tagcloud (Intersection) ?