INVS and ZNF512B

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		INVS	ZNF512B
Description		inversin	zinc finger protein 512B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytoskeleton Microtubule Cilium Membrane Cell Projection	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Calmodulin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Kidney Development Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Protein Localization To Ciliary Inversin Compartment	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription
Pathways			RHOV GTPase cycle
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Macular thickness ( 30535121) Preeclampsia ( 23551011)	Birth weight ( 31043758) Mean platelet volume ( 32888494) Offspring birth weight ( 31043758) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		4 interacting genes: CALM2 HIF1AN NPHP1 ZNF512B	72 interacting genes: AJUBA ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BANP BRD1 BTBD2 C11orf68 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 GOLGA2 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MDFI MEOX2 MTUS2 MYH10 NACC1 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RABEP1 RPS27A RSPH1 SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2 ZNF143 ZYX
Entrez ID		27130	57473
HPRD ID		08356	13840
Ensembl ID		ENSG00000119509	ENSG00000196700
Uniprot IDs		Q2M1I4 Q9Y283	Q96KM6
PDB IDs			2GQJ 8TX8
Enriched GO Terms of Interacting Partners?		Response To Vitamin B3 Apolipoprotein A-I-mediated Signaling Pathway Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Lipoprotein Biosynthetic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Phosphatidylcholine Floppase Activity Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Localization Involved In Establishment Of Planar Polarity [protein]-asparagine 3-dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Peptidyl-histidine Dioxygenase Activity Oxygen Sensor Activity Positive Regulation Of Sequestering Of Calcium Ion Ankyrin Repeat Binding Carboxylic Acid Binding High-density Lipoprotein Particle Assembly Phospholipid Efflux High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction ATPase-coupled Intramembrane Lipid Transporter Activity Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Titin Binding Adenylate Cyclase Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Bicellular Tight Junction Assembly Spermatid Differentiation Positive Regulation Of Vasculogenesis	Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Wnt Signaling Pathway Chromosome Unmethylated CpG Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Biosynthetic Process Metal Ion Binding Chromatin Remodeling Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Chromatin DEAD/H-box RNA Helicase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Primary MiRNA Binding Protein Phosphatase Regulator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cellular Response To Cocaine Thioesterase Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cellular Component Organization Primary MiRNA Processing
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