INVS and NPHP1

Number of citations of the paper that reports this interaction (PubMedID 12872123)
49

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		INVS	NPHP1
Description		inversin	nephrocystin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytoskeleton Microtubule Cilium Membrane Cell Projection	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Bicellular Tight Junction Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Calmodulin Binding	Structural Molecule Activity Protein Binding
	Biological Process	Kidney Development Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Protein Localization To Ciliary Inversin Compartment	Signal Transduction Spermatogenesis Visual Behavior Cell Projection Organization Actin Cytoskeleton Organization Cell Differentiation Spermatid Differentiation Retina Development In Camera-type Eye Protein Localization Involved In Establishment Of Planar Polarity Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly
Pathways			Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)	Joubert syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Macular thickness ( 30535121) Preeclampsia ( 23551011)
Interacting Genes		4 interacting genes: CALM2 HIF1AN NPHP1 ZNF512B	16 interacting genes: ADAM15 ARHGAP32 BCAR1 FBXO7 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4
Entrez ID		27130	4867
HPRD ID		08356	09524
Ensembl ID		ENSG00000119509	ENSG00000144061
Uniprot IDs		Q2M1I4 Q9Y283	B4DQY0 C9JNM7 O15259
PDB IDs			1S1N 6O1Q
Enriched GO Terms of Interacting Partners?		Response To Vitamin B3 Apolipoprotein A-I-mediated Signaling Pathway Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Lipoprotein Biosynthetic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Phosphatidylcholine Floppase Activity Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Localization Involved In Establishment Of Planar Polarity [protein]-asparagine 3-dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Peptidyl-histidine Dioxygenase Activity Oxygen Sensor Activity Positive Regulation Of Sequestering Of Calcium Ion Ankyrin Repeat Binding Carboxylic Acid Binding High-density Lipoprotein Particle Assembly Phospholipid Efflux High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction ATPase-coupled Intramembrane Lipid Transporter Activity Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Titin Binding Adenylate Cyclase Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Bicellular Tight Junction Assembly Spermatid Differentiation Positive Regulation Of Vasculogenesis	Regulation Of Cellular Component Organization Anchoring Junction Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Cell Surface Receptor Signaling Pathway Cytosol Cell Projection Cell Cortex Signal Transduction Endothelin Receptor Signaling Pathway Apical Dendrite Integrin-mediated Signaling Pathway Protein Localization To Cell-cell Junction Actin Cytoskeleton SH3 Domain Binding Developmental Process Cytoplasm Regulation Of Apoptotic Process Cytoskeleton Organization Immune System Process Z Disc Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Programmed Cell Death Actin Cytoskeleton Organization Neurotransmitter Receptor Regulator Activity Perinuclear Region Of Cytoplasm Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Actin Filament-based Process Kidney Development BIM-BCL-2 Complex BIM-BCL-xl Complex Grb2-Sos Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Determination Of Stomach Left/right Asymmetry Photoreceptor Cell Maintenance Determination Of Intestine Left/right Asymmetry Negative Regulation Of Wnt Signaling Pathway Ciliary Base Protein Localization To Ciliary Inversin Compartment Protein Kinase Binding Actin Filament Binding Cell-cell Junction Regulation Of Cell-substrate Adhesion Cell Adhesion Positive Regulation Of Cellular Component Biogenesis Regulation Of Signal Transduction
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