INVS and HIF1AN

Number of citations of the paper that reports this interaction (PubMedID 26972000)
43

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		INVS	HIF1AN
Description		inversin	hypoxia inducible factor 1 subunit alpha inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytoskeleton Microtubule Cilium Membrane Cell Projection	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Calmodulin Binding	Transcription Corepressor Activity Notch Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity [protein]-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Metal Ion Binding NF-kappaB Binding Dioxygenase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-aspartic Acid 3-dioxygenase Activity Ankyrin Repeat Binding
	Biological Process	Kidney Development Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Protein Localization To Ciliary Inversin Compartment	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Vasculogenesis
Pathways			Cellular response to hypoxia
Drugs			D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Macular thickness ( 30535121) Preeclampsia ( 23551011)	Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293)
Interacting Genes		4 interacting genes: CALM2 HIF1AN NPHP1 ZNF512B	17 interacting genes: ANKRD12 ANKRD37 ANKRD50 ASB13 ASB4 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL
Entrez ID		27130	55662
HPRD ID		08356	09426
Ensembl ID		ENSG00000119509	ENSG00000166135
Uniprot IDs		Q2M1I4 Q9Y283	Q9NWT6
PDB IDs			1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6 6RUJ 7A1J 7A1K 7A1L 7A1M 7A1N 7A1O 7A1P 7A1Q 7A1S 8IHZ 8II0 8K71 8K72 8K73 9FSN 9IIF
Enriched GO Terms of Interacting Partners?		Response To Vitamin B3 Apolipoprotein A-I-mediated Signaling Pathway Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Lipoprotein Biosynthetic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Phosphatidylcholine Floppase Activity Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Localization Involved In Establishment Of Planar Polarity [protein]-asparagine 3-dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Peptidyl-histidine Dioxygenase Activity Oxygen Sensor Activity Positive Regulation Of Sequestering Of Calcium Ion Ankyrin Repeat Binding Carboxylic Acid Binding High-density Lipoprotein Particle Assembly Phospholipid Efflux High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction ATPase-coupled Intramembrane Lipid Transporter Activity Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Titin Binding Adenylate Cyclase Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Bicellular Tight Junction Assembly Spermatid Differentiation Positive Regulation Of Vasculogenesis	Protein Lysine Delactylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity NF-kappaB Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Protein De-2-hydroxyisobutyrylase Activity Enzyme Binding Fungiform Papilla Formation Protein Modification Process Histone Deacetylase Binding Hair Follicle Placode Formation Histone Deacetylase Complex Transcription Corepressor Binding Cytosol DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Deacetylase Activity P53 Binding Protein Deacetylation Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Cul5-RING Ubiquitin Ligase Complex NuRD Complex Protein Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Negative Regulation Of Signal Transduction Regulation Of Cell Fate Specification Regulation Of Apoptotic Process Protein Ubiquitination Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Circadian Rhythm Regulation Of Programmed Cell Death Heterochromatin Formation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Amyloid Fibril Formation Regulation Of TOR Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Glial Cell Differentiation Nucleosomal DNA Binding Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Intracellular Signal Transduction
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