INVS and HIF1AN

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		INVS	HIF1AN
Gene Name		inversin	hypoxia inducible factor 1, alpha subunit inhibitor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Spindle Microtubule Membrane Ciliary Inversin Compartment Ciliary Base	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Calmodulin Binding	Notch Binding Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Cofactor Binding NF-kappaB Binding Ankyrin Repeat Binding
	Biological Process	Kidney Development Post-embryonic Development Wnt Signaling Pathway Pancreas Development Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway	Transcription, DNA-templated Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Positive Regulation Of Vasculogenesis
Pathways			Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS		Preeclampsia ( 23551011)	Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		4 interactors: CALM2 HIF1AN NPHP1 ZNF512B	13 interactors: ASB13 ASB4 ASB9 FBF1 FEM1B HDAC1 HDAC2 HDAC3 HIF1A INVS NFKB1 UACA VHL
Entrez ID		27130	55662
HPRD ID		08356	09426
Ensembl ID		ENSG00000119509
Uniprot IDs		F5GZH2 Q2M1I4 Q9Y283	Q9NWT6
PDB IDs			1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO
Enriched GO Terms of Interacting Partners?		Peptidyl-histidine Hydroxylation Peptidyl-asparagine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Response To Abiotic Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of High Voltage-gated Calcium Channel Activity Response To Light Stimulus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Photoreceptor Cell Outer Segment Organization Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Positive Regulation Of Vasculogenesis Regulation Of Cell Communication By Electrical Coupling Response To Radiation Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Regulation Of Vasculogenesis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Myoblast Differentiation Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Protein Hydroxylation Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Positive Regulation Of Phosphatase Activity Negative Regulation Of Notch Signaling Pathway Response To Corticosterone Positive Regulation Of Cation Channel Activity Response To Amphetamine Regulation Of Phosphoprotein Phosphatase Activity	Positive Regulation Of Receptor Biosynthetic Process Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of Apoptotic Process Regulation Of Cell Death Histone H3 Deacetylation Histone H3-K9 Modification Histone Deacetylation Negative Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Protein Deacetylation Negative Regulation Of Programmed Cell Death Neurotrophin Signaling Pathway Negative Regulation Of Cell Death Fungiform Papilla Formation Circadian Regulation Of Gene Expression Protein Ubiquitination Fungiform Papilla Morphogenesis Negative Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Fungiform Papilla Development Eyelid Development In Camera-type Eye Negative Regulation Of Signaling Hair Follicle Placode Formation Regulation Of Signal Transduction Tongue Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Epithelial Cell Maturation Notch Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Differentiation Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Signaling Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cell Communication Circadian Rhythm Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Tongue Development Epithelial Cell Differentiation Positive Regulation Of Cellular Metabolic Process Epithelium Development
Tagcloud ?		adjunct attempted chromogranin clarify colitis comparatively coordinately crucially diffuse dysplasia dysplasias focal grading hgd hgds immunoreactive lgd lgds mucosa neoplasia neoplastic neuroendocrine pancellular positivity predictive tended uc ulcerative utility	bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1
Tagcloud (Difference) ?		adjunct attempted chromogranin clarify colitis comparatively coordinately crucially diffuse dysplasia dysplasias focal grading hgd hgds immunoreactive lgd lgds mucosa neoplasia neoplastic neuroendocrine pancellular positivity predictive tended uc ulcerative utility	bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1
Tagcloud (Intersection) ?