ZNF446 and ZNF165

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		ZNF446	ZNF165
Gene Name		zinc finger protein 446	zinc finger protein 165
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus	Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: ACTN2 DGCR6 DGCR6L FHL5 KRT40 KRTAP10-3 LZTS2 NOTCH2NL PGBD1 PIN1 SUFU TRIM27 ZKSCAN7 ZNF165 ZNF232 ZNF24 ZNF263 ZNF396 ZNF397 ZNF496 ZSCAN16 ZSCAN21 ZSCAN22 ZSCAN32 ZSCAN9	22 interactors: AHCYL1 CCDC130 CCDC85B DVL2 EMD EWSR1 FAM124A GPATCH2L KAT7 KRT40 KRTAP10-3 KRTAP10-7 KRTAP4-12 MID2 PDLIM7 SCAND1 SUV39H1 TCEB3B ZKSCAN8 ZNF24 ZNF250 ZNF446
Entrez ID		55663	7718
HPRD ID		07934	02903
Ensembl ID		ENSG00000083838	ENSG00000197279
Uniprot IDs		Q9NWS9	P49910 Q53Z40
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Ion Transport Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Localization Negative Regulation Of Transport Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Negative Regulation Of Calcium Ion Import Microspike Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Localization To Cell Surface Interferon-gamma Secretion Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Spindle Midzone Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cellular Process Cellular Metabolic Process Convergent Extension Involved In Neural Plate Elongation Transcription From RNA Polymerase II Promoter S-adenosylmethionine Cycle Convergent Extension Involved In Organogenesis Histone H3-K9 Dimethylation Protein Localization To Microtubule Negative Regulation Of RNA Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Neural Plate Morphogenesis Mitotic Nuclear Envelope Reassembly Histone H4-K12 Acetylation Histone H3-K9 Trimethylation Negative Regulation Of Catenin Import Into Nucleus Nuclear Envelope Reassembly Peptidyl-lysine Dimethylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H4-K5 Acetylation Histone H4-K8 Acetylation Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Gene Expression Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Biosynthetic Process Convergent Extension Negative Regulation Of Viral Release From Host Cell Chromatin Silencing At RDNA Negative Regulation Of Viral Entry Into Host Cell Regulation Of MRNA 3'-end Processing
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