ZNF446 and ZNF496

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		ZNF446	ZNF496
Description		zinc finger protein 446	zinc finger protein 496
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Space Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways		Generic Transcription Pathway	Generic Transcription Pathway
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Uric acid clearance ( 28095793)	Chromium levels ( 26025379) Platelet distribution width ( 32888494)
Interacting Genes		54 interacting genes: ACTN2 ANKRD1 CCNK COPS2 CYSRT1 DGCR6 DGCR6L EHMT2 EVI5 FHL5 FRMD8 FRS3 GOLGA6L9 INCA1 KIFC3 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP3-1 LNX1 LZTS2 MAGOHB MDFI NBPF19 NOTCH2NLA PIN1 REL SCAND1 SIVA1 SUFU TAX1BP1 TRIM27 UBE2I UBE3A ZKSCAN7 ZNF165 ZNF18 ZNF232 ZNF24 ZNF263 ZNF496 ZSCAN12 ZSCAN16 ZSCAN18 ZSCAN21 ZSCAN22 ZSCAN29 ZSCAN30 ZSCAN32 ZSCAN9	22 interacting genes: ARR3 CBX3 JADE2 NR3C1 NSD1 PGBD1 POLR3D PPARG RAI1 RNF8 SCAND1 SSX3 SUMO2 SUMO3 SUPT5H TRIM28 ZKSCAN4 ZNF446 ZSCAN12 ZSCAN21 ZSCAN22 ZZZ3
Entrez ID		55663	84838
HPRD ID		07934	15805
Ensembl ID		ENSG00000083838	ENSG00000162714
Uniprot IDs		Q9NWS9	Q96IT1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Keratin Filament Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Regulation Of Gene Expression Structural Constituent Of Skin Epidermis Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Binding Nucleus Regulation Of Metabolic Process Intermediate Filament Organization Metal Ion Binding Postsynaptic Cytosol Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Molecule Activity Protein Binding Sequence-specific Double-stranded DNA Binding Titin Binding	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Zinc Ion Binding Nucleus Chromatin Binding Nucleoplasm RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Sumoylation Chromatin Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Tag Activity DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Positive Regulation Of RNA Metabolic Process SUMO Transferase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Ubiquitin-like Protein Ligase Binding Negative Regulation Of DNA-templated Transcription, Elongation Cellular Response To Dexamethasone Stimulus RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Nuclear Glucocorticoid Receptor Activity Transcription Coregulator Binding Chromatin Remodeling Response To Dexamethasone Regulation Of DNA Binding Negative Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Heterochromatin Positive Regulation Of Metabolic Process Cellular Response To Glucocorticoid Stimulus Positive Regulation Of MiRNA Transcription Nuclear Receptor Activity Chromatin Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
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