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ZNF446 and ACTN2
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
ZNF446
ACTN2
Gene Name
zinc finger protein 446
actinin, alpha 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleus
Extracellular Region
Cytosol
Cytoskeleton
Actin Filament
Focal Adhesion
Z Disc
Filopodium
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Dendritic Spine
Extracellular Vesicular Exosome
Molecular Function
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
DNA Binding
Metal Ion Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
LIM Domain Binding
Thyroid Hormone Receptor Coactivator Activity
Titin Binding
Identical Protein Binding
Ion Channel Binding
Protein Dimerization Activity
Actin Filament Binding
FATZ Binding
Titin Z Domain Binding
Biological Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Platelet Degranulation
Cell Adhesion
Synaptic Transmission
Blood Coagulation
Microspike Assembly
Muscle Filament Sliding
Platelet Activation
Regulation Of Membrane Potential
Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Potassium Ion Transport
Focal Adhesion Assembly
Protein Homotetramerization
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Receptor Activity
Pathways
Generic Transcription Pathway
Striated Muscle Contraction
Platelet degranulation
CREB phosphorylation through the activation of Ras
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Response to elevated platelet cytosolic Ca2+
CREB phosphorylation through the activation of CaMKII
Nephrin interactions
Platelet activation, signaling and aggregation
Unblocking of NMDA receptor, glutamate binding and activation
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Ras activation uopn Ca2+ infux through NMDA receptor
Transmission across Chemical Synapses
Post NMDA receptor activation events
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
25 interactors:
ACTN2
DGCR6
DGCR6L
FHL5
KRT40
KRTAP10-3
LZTS2
NOTCH2NL
PGBD1
PIN1
SUFU
TRIM27
ZKSCAN7
ZNF165
ZNF232
ZNF24
ZNF263
ZNF396
ZNF397
ZNF496
ZSCAN16
ZSCAN21
ZSCAN22
ZSCAN32
ZSCAN9
59 interactors:
ACTN3
ADAM12
ADORA2A
ANG
ATXN2
ATXN7
BRMS1L
CAMK2A
CAMK2D
CAMK2G
CAPN1
COIL
DISC1
DLG1
DLG4
EPS8L1
ERBB2IP
FAM154A
FBXL22
GRIN1
GRIN2B
ITGB3BP
KAT2B
KCNA4
KCNA5
KCNN2
LDB3
LRP12
LRRC7
MED14
MICALL2
MOS
MYOZ1
MYOZ2
MYOZ3
MYPN
NCOA2
NCOR1
NOS3
NR1I2
NRIP1
PALLD
PDLIM1
PDLIM3
PKD2
RAVER1
RPL35
RTP5
SELE
SNAI1
SNW1
SP100
SSX2IP
ST7
SYNPO2
TNN
TTN
UTRN
ZNF446
Entrez ID
55663
88
HPRD ID
07934
00019
Ensembl ID
ENSG00000083838
ENSG00000077522
Uniprot IDs
Q9NWS9
B2RCS5
P35609
Q59FD9
PDB IDs
1H8B
1HCI
1QUU
Enriched GO Terms of Interacting Partners
?
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
RNA Metabolic Process
Regulation Of Metabolic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Cellular Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transmembrane Transport
Negative Regulation Of Interleukin-2 Secretion
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Ion Transport
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Localization
Negative Regulation Of Transport
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Negative Regulation Of Calcium Ion Import
Microspike Assembly
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Protein Localization To Cell Surface
Interferon-gamma Secretion
Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Spindle Midzone Assembly
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Cytoskeleton Organization
Regulation Of Ion Transport
Organelle Organization
Cell Communication
Actin Filament-based Process
Signaling
Cellular Component Assembly
Positive Regulation Of Cellular Metabolic Process
Regulation Of Ion Transmembrane Transport
Anatomical Structure Development
Synaptic Transmission
Positive Regulation Of Metabolic Process
Cell Development
Signal Transduction
Movement Of Cell Or Subcellular Component
Cell Differentiation
Cell-cell Signaling
Regulation Of Cellular Process
Rhythmic Process
Developmental Process
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Receptor Signaling Pathway
Actin Cytoskeleton Organization
Anatomical Structure Morphogenesis
Protein Complex Assembly
Regulation Of Potassium Ion Transport
Striated Muscle Cell Differentiation
Regulation Of Signaling
Anatomical Structure Formation Involved In Morphogenesis
Response To Organic Substance
Regulation Of Sodium Ion Transport
Response To Abiotic Stimulus
Muscle System Process
Negative Regulation Of Transport
Striated Muscle Cell Development
Positive Regulation Of Cellular Biosynthetic Process
Myofibril Assembly
Establishment Or Maintenance Of Apical/basal Cell Polarity
Transcription Initiation From RNA Polymerase II Promoter
Cell Adhesion
Muscle Cell Development
Cellular Calcium Ion Homeostasis
Regulation Of Receptor Internalization
Regulation Of Cellular Response To Heat
Response To Stimulus
Regulation Of Histone Deacetylase Activity
Calcium Ion Homeostasis
Regulation Of Calcium Ion Transport
Locomotion
Negative Regulation Of Ion Transport
Tagcloud
?
actinin
barr
cd99
cdk8
dnajb2
e2f
e2f2
ebv
epstein
fatigue
hsp40
hybridized
indicative
infectious
infective
irritability
isg20
malaise
microarrays
mononucleosis
oligonucleotides
pbmc
persist
pilot
recovered
resolve
somnolence
spotted
uneventfully
Tagcloud (Difference)
?
actinin
barr
cd99
cdk8
dnajb2
e2f
e2f2
ebv
epstein
fatigue
hsp40
hybridized
indicative
infectious
infective
irritability
isg20
malaise
microarrays
mononucleosis
oligonucleotides
pbmc
persist
pilot
recovered
resolve
somnolence
spotted
uneventfully
Tagcloud (Intersection)
?