ZNF446 and FHL5

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZNF446	FHL5
Gene Name		zinc finger protein 446	four and a half LIM domains 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus	Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter	Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Coronary heart disease ( 22319020) Migraine ( 22683712)
Protein-Protein Interactions		25 interactors: ACTN2 DGCR6 DGCR6L FHL5 KRT40 KRTAP10-3 LZTS2 NOTCH2NL PGBD1 PIN1 SUFU TRIM27 ZKSCAN7 ZNF165 ZNF232 ZNF24 ZNF263 ZNF396 ZNF397 ZNF496 ZSCAN16 ZSCAN21 ZSCAN22 ZSCAN32 ZSCAN9	12 interactors: COIL CREB1 CREM DNAL4 FHL2 FHL3 HOXA1 KIF17 SMAD1 SRF STX11 ZNF446
Entrez ID		55663	9457
HPRD ID		07934	05497
Ensembl ID		ENSG00000083838	ENSG00000112214
Uniprot IDs		Q9NWS9	Q5TD97
PDB IDs			1X68
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Ion Transport Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Localization Negative Regulation Of Transport Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Negative Regulation Of Calcium Ion Import Microspike Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Localization To Cell Surface Interferon-gamma Secretion Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Spindle Midzone Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Heart Trabecula Formation RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Heart Trabecula Morphogenesis Cardiac Muscle Tissue Development RNA Metabolic Process Tube Development Trabecula Morphogenesis Multicellular Organismal Development Cell Differentiation Gene Expression Cognition Brain Development Artery Morphogenesis Striated Muscle Tissue Development Cellular Macromolecule Biosynthetic Process Head Development Macromolecule Biosynthetic Process Muscle Tissue Development Artery Development Positive Regulation Of Cellular Metabolic Process Cardiac Muscle Cell Development Cardiovascular System Development Transcription From RNA Polymerase II Promoter Abducens Nerve Formation Contractile Actin Filament Bundle Assembly Optokinetic Behavior Neurogenesis Developmental Process Mesoderm Formation Central Nervous System Development Mesoderm Morphogenesis System Development Cellular Response To Organic Substance Facial Nucleus Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Single-organism Behavior Organ Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Pattern Specification Process Cardiac Muscle Cell Differentiation
Tagcloud ?			1p13 1p36 5x10 6q16 7p14 8q21 affecting ajap1 apoa1bp atp5b c7orf10 candidate fut9 loci locus matched meta migraine mmp16 near poorly stat6 subgroup susceptibility tbc1d7 trait tspan2 understood wide
Tagcloud (Difference) ?			1p13 1p36 5x10 6q16 7p14 8q21 affecting ajap1 apoa1bp atp5b c7orf10 candidate fut9 loci locus matched meta migraine mmp16 near poorly stat6 subgroup susceptibility tbc1d7 trait tspan2 understood wide
Tagcloud (Intersection) ?