PTPRJ and CTNND1

Number of citations of the paper that reports this interaction (PMID 12370829)
19

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro, in vivo)

		PTPRJ	CTNND1
Gene Name		protein tyrosine phosphatase, receptor type, J	catenin (cadherin-associated protein), delta 1
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Cell Junction Ruffle Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Lamellipodium Growth Cone Midbody Dendritic Spine Synapse Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	Receptor Binding Protein Binding Protein Kinase Binding Cadherin Binding
	Biological Process	Vasculogenesis Heart Development Blood Coagulation Negative Regulation Of Cell Proliferation Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Negative Regulation Of Receptor Activity	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion Brain Development Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) D-dimer levels ( 21502573) Height ( 23563607)
Protein-Protein Interactions		11 interactors: CTNNB1 CTNND1 EGFR IL2RG JUP LAT MET NOP2 PDGFRB PLCG1 SDCBP	26 interactors: ACTA1 APP CDH1 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR ERBB2IP FER GRIK2 GSK3B JUP KCTD6 LCK MTNR1B MUC1 PSEN1 PTPN6 PTPRJ PTPRM SNCA SRC YWHAG ZBTB33
Entrez ID		5795	1500
HPRD ID		02955	03026
Ensembl ID		ENSG00000149177	ENSG00000198561
Uniprot IDs		Q12913 Q9NPR5	C9JZR2 O60716
PDB IDs		2CFV 2DLE 2NZ6	3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of MAPK Cascade Regulation Of Signal Transduction Locomotion Positive Regulation Of Transport Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Cellular Response To Indole-3-methanol Single Organismal Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Signal Transduction Fc-epsilon Receptor Signaling Pathway Response To External Stimulus Chemotaxis Signaling Fc Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Cell Communication Adherens Junction Organization Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Component Movement Immune Response Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorylation Calcium-mediated Signaling Positive Regulation Of Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Estradiol Axon Guidance Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Second-messenger-mediated Signaling Metanephric Nephron Morphogenesis Regulation Of Cell Fate Specification	Cell Adhesion Adherens Junction Organization Regulation Of Signaling Single Organismal Cell-cell Adhesion Regulation Of Signal Transduction Regulation Of Cellular Localization Regulation Of Intracellular Transport Cellular Response To Organonitrogen Compound Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Junction Assembly Cell-cell Junction Organization Locomotion Cellular Response To Stimulus Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Regulation Of ERBB Signaling Pathway Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Signal Transduction Regulation Of Protein Kinase Activity Response To Drug Programmed Cell Death Cell Death Death Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Developmental Process Negative Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Response To Mechanical Stimulus Anatomical Structure Development Response To Organonitrogen Compound Response To External Stimulus Regulation Of Apoptotic Process Cell Migration Regulation Of Cell Proliferation Positive Regulation Of Intracellular Transport
Tagcloud ?		10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy cebpe chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition relapsed runx1 sibs tp63 twinned	abi1 atlas bitbucket ccnd3 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy cebpe chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition relapsed runx1 sibs tp63 twinned	abi1 atlas bitbucket ccnd3 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?