PTPRJ and BAAT

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		PTPRJ	BAAT
Description		protein tyrosine phosphatase receptor type J	bile acid-CoA:amino acid N-acyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleoplasm Nucleolus Plasma Membrane Cell-cell Junction Cell Surface Membrane Nuclear Body Cell Junction Ruffle Membrane Specific Granule Membrane Cell Projection Extracellular Exosome Anchoring Junction	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	Protein Binding N-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Thiolester Hydrolase Activity Choloyl-CoA Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity Glycine N-choloyltransferase Activity Carboxylic Ester Hydrolase Activity Medium-chain Fatty Acyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity
	Biological Process	Angiogenesis Vasculogenesis Positive Regulation Of Cell-matrix Adhesion Immune System Process Signal Transduction Axon Guidance Heart Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Cytokine-mediated Signaling Pathway Hemopoiesis Regulation Of Cell Adhesion B Cell Differentiation Platelet Formation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Glucose Homeostasis Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Negative Regulation Of Insulin Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Contact Inhibition Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction	Liver Development Bile Acid Conjugation Glycine Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Bile Acid Metabolic Process Taurine Metabolic Process Animal Organ Regeneration Monocarboxylic Acid Metabolic Process
Pathways		Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3	Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Peroxisomal protein import Peroxisomal protein import
Drugs			Glycine
Diseases			Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alanine aminotransferase levels ( 33547301) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Caffeine consumption from coffee or tea ( 33287642) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31879980) Intraocular pressure ( 31798171 31959993 30054594 29785010 29617998 29235454 25173106) Kawasaki disease ( 33692975) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 33838163) Sleep duration (short sleep) ( 30846698)
Interacting Genes		37 interacting genes: ANP32B BAAT BAP1 CASC3 CNKSR1 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 FANCC FBP1 HEMGN HOXC6 HRAS IL2RG JUP KLK7 KLK9 LAT LYPD3 MAP2K1 MET NANS NOP2 PDGFRB PLCG1 PPP2CB PPP3R2 PRDM14 RASA1 SDCBP SFRP4 TMEFF1 TRMO TSTD2 ZNF510	24 interacting genes: APC AURKA BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 GOLGA8DP GOLGA8EP GOLGA8F MCC MLH1 MLH3 MUTYH ODC1 PDGFRL PEX5 PTPRJ RAD54B RB1 SLC7A11 SMAD4 SRC
Entrez ID		5795	570
HPRD ID		02955	08376
Ensembl ID		ENSG00000149177	ENSG00000136881
Uniprot IDs		Q12913 Q9NPR5	Q14032
PDB IDs		2CFV 2DLE 2NZ6 7U01 7U08
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Catenin-TCF7L2 Complex Phospholipase C Activator Activity ERBB Signaling Pathway Cellular Response To Indole-3-methanol Positive Regulation Of MAPK Cascade Catenin Complex Cell Morphogenesis Protein Phosphatase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Signal Transduction Response To Indole-3-methanol Cell-cell Junction Trachea Formation Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Regulation Of Ras Protein Signal Transduction Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activity Alpha-catenin Binding Phosphatase Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Vasculature Development Regulation Of Cell Motility Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Transport Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Transport Intracellular Signaling Cassette Tube Morphogenesis Regulation Of MAPK Cascade Histone Methyltransferase Binding Regulation Of Cell Population Proliferation Ciliary Basal Body Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Adherens Junction	Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Ruffle Membrane Regulation Of Protein Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Gamma-catenin Binding Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Chiasma Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Cell Population Proliferation Reciprocal Meiotic Recombination Mismatch Repair Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Phosphorylation Response To Stress Regulation Of Protein Modification Process Regulation Of Mitotic Nuclear Division Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Programmed Cell Death Homologous Recombination Mismatch Repair Complex Cellular Response To Stress Negative Regulation Of Immature T Cell Proliferation Regulation Of Cell-matrix Adhesion Regulation Of Cellular Component Organization MutSalpha Complex Binding Regulation Of Nuclear Division Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Apoptotic Signaling Pathway Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Growth Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell-substrate Adhesion Regulation Of Catalytic Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Mismatched DNA Binding
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