PTPRJ and NOP2

Number of citations of the paper that reports this interaction (PMID 12370829)
19

Data Source:
HPRD (in vitro, in vivo)

		PTPRJ	NOP2
Gene Name		protein tyrosine phosphatase, receptor type, J	NOP2 nucleolar protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Cell Junction Ruffle Membrane Extracellular Vesicular Exosome	Nucleolus
	Molecular Function	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	Protein Binding S-adenosylmethionine-dependent Methyltransferase Activity Poly(A) RNA Binding
	Biological Process	Vasculogenesis Heart Development Blood Coagulation Negative Regulation Of Cell Proliferation Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Negative Regulation Of Receptor Activity	RRNA Processing Positive Regulation Of Cell Proliferation Methylation
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) D-dimer levels ( 21502573) Height ( 23563607)
Protein-Protein Interactions		11 interactors: CTNNB1 CTNND1 EGFR IL2RG JUP LAT MET NOP2 PDGFRB PLCG1 SDCBP	8 interactors: CDCA7L CEP70 KPNA6 MCRS1 MT1F NPM1 PTPRJ VPS52
Entrez ID		5795	4839
HPRD ID		02955	01244
Ensembl ID		ENSG00000149177	ENSG00000111641
Uniprot IDs		Q12913 Q9NPR5	P46087
PDB IDs		2CFV 2DLE 2NZ6
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of MAPK Cascade Regulation Of Signal Transduction Locomotion Positive Regulation Of Transport Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Cellular Response To Indole-3-methanol Single Organismal Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Signal Transduction Fc-epsilon Receptor Signaling Pathway Response To External Stimulus Chemotaxis Signaling Fc Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Cell Communication Adherens Junction Organization Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Component Movement Immune Response Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorylation Calcium-mediated Signaling Positive Regulation Of Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Estradiol Axon Guidance Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Second-messenger-mediated Signaling Metanephric Nephron Morphogenesis Regulation Of Cell Fate Specification	Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Embryonic Ectodermal Digestive Tract Development Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity
Tagcloud ?		10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy cebpe chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition relapsed runx1 sibs tp63 twinned	assumed ca1 carotid cingulate dense differentiating fibrillar heterozygous histochemistry homozygous immunoelectron infragranular lethality mature nestin nop2gt1gaj nucleolar nucleolus occlusion periventricular pyramidal regeneration ribosomes somatosensory strokes subcellular subiculum supragranular vital
Tagcloud (Difference) ?		10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy cebpe chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition relapsed runx1 sibs tp63 twinned	assumed ca1 carotid cingulate dense differentiating fibrillar heterozygous histochemistry homozygous immunoelectron infragranular lethality mature nestin nop2gt1gaj nucleolar nucleolus occlusion periventricular pyramidal regeneration ribosomes somatosensory strokes subcellular subiculum supragranular vital
Tagcloud (Intersection) ?