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PTPRJ and PLCG1
Number of citations of the paper that reports this interaction (PubMedID
11259588
)
56
Data Source:
HPRD
(in vitro)
PTPRJ
PLCG1
Description
protein tyrosine phosphatase receptor type J
phospholipase C gamma 1
Image
GO Annotations
Cellular Component
Immunological Synapse
Extracellular Region
Nucleoplasm
Nucleolus
Plasma Membrane
Cell-cell Junction
Cell Surface
Membrane
Nuclear Body
Cell Junction
Ruffle Membrane
Specific Granule Membrane
Cell Projection
Extracellular Exosome
Anchoring Junction
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
COP9 Signalosome
Lamellipodium
Ruffle Membrane
Cell Projection
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Beta-catenin Binding
Hydrolase Activity
Phosphatase Activity
Protein Kinase Binding
Gamma-catenin Binding
Cadherin Binding
Mitogen-activated Protein Kinase Binding
Delta-catenin Binding
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Phospholipase C Activity
Guanyl-nucleotide Exchange Factor Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Phosphoric Diester Hydrolase Activity
Hydrolase Activity
Protein Kinase Binding
Metal Ion Binding
Calcium-dependent Phospholipase C Activity
Phosphatidylinositol Phospholipase C Activity
Biological Process
Angiogenesis
Vasculogenesis
Positive Regulation Of Cell-matrix Adhesion
Immune System Process
Signal Transduction
Axon Guidance
Heart Development
Blood Coagulation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Positive Regulation Of Platelet Activation
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Macrophage Chemotaxis
Cytokine-mediated Signaling Pathway
Hemopoiesis
Regulation Of Cell Adhesion
B Cell Differentiation
Platelet Formation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Positive Regulation Of Tumor Necrosis Factor Production
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Glucose Homeostasis
Negative Regulation Of Vascular Permeability
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Adhesion
Negative Regulation Of Insulin Receptor Signaling Pathway
Platelet-derived Growth Factor Receptor Signaling Pathway
Oligodendrocyte Differentiation
Positive Regulation Of Phagocytosis
Positive Regulation Of Immune Response
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Positive Chemotaxis
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Contact Inhibition
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of Biological Quality
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Lipid Metabolic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Lipid Catabolic Process
Cell Migration
Calcium-mediated Signaling
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Phosphatidylinositol-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Sequestering Of Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Phosphorylation of CD3 and TCR zeta chains
Neutrophil degranulation
Negative regulation of MET activity
Negative regulation of FLT3
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Signaling by ALK
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS
Acute lymphoblastic leukemia (childhood) (
22076464
)
Alanine aminotransferase levels (
33547301
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Caffeine consumption from coffee or tea (
33287642
)
D-dimer levels (
21502573
)
Experiencing mood swings (
29500382
)
Heel bone mineral density (
30598549
)
Height (
28552196
25282103
23563607
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hypertension (
31879980
)
Intraocular pressure (
31798171
31959993
30054594
29785010
29617998
29235454
25173106
)
Kawasaki disease (
33692975
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Serum alkaline phosphatase levels (
33547301
)
Serum metabolite concentrations in chronic kidney disease (
33838163
)
Sleep duration (short sleep) (
30846698
)
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
37 interacting genes:
ANP32B
BAAT
BAP1
CASC3
CNKSR1
CTNNB1
CTNND1
CYP17A1
EGFR
EPSTI1
FANCC
FBP1
HEMGN
HOXC6
HRAS
IL2RG
JUP
KLK7
KLK9
LAT
LYPD3
MAP2K1
MET
NANS
NOP2
PDGFRB
PLCG1
PPP2CB
PPP3R2
PRDM14
RASA1
SDCBP
SFRP4
TMEFF1
TRMO
TSTD2
ZNF510
112 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RBM11
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
Entrez ID
5795
5335
HPRD ID
02955
01398
Ensembl ID
ENSG00000149177
ENSG00000124181
Uniprot IDs
Q12913
Q9NPR5
P19174
PDB IDs
2CFV
2DLE
2NZ6
7U01
7U08
1HSQ
2HSP
4EY0
4FBN
7NXE
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Catenin-TCF7L2 Complex
Phospholipase C Activator Activity
ERBB Signaling Pathway
Cellular Response To Indole-3-methanol
Positive Regulation Of MAPK Cascade
Catenin Complex
Cell Morphogenesis
Protein Phosphatase Binding
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Locomotion
Positive Regulation Of Cell Motility
Regulation Of Signal Transduction
Response To Indole-3-methanol
Cell-cell Junction
Trachea Formation
Regulation Of Blood Vessel Branching
Regulation Of Calcium Ion Import
Regulation Of Ras Protein Signal Transduction
Positive Regulation Of Cell Migration
Protein Tyrosine Kinase Activity
Alpha-catenin Binding
Phosphatase Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphorylation
Vasculature Development
Regulation Of Cell Motility
Focal Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Transport
Regulation Of Signaling
Regulation Of Locomotion
Negative Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Transport
Intracellular Signaling Cassette
Tube Morphogenesis
Regulation Of MAPK Cascade
Histone Methyltransferase Binding
Regulation Of Cell Population Proliferation
Ciliary Basal Body
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Protein Localization
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Ras Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Adherens Junction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Activity
Plasma Membrane
Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Phosphorylation
Regulation Of Signal Transduction
Protein Autophosphorylation
Positive Regulation Of Signal Transduction
Cell Migration
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Receptor Complex
Antigen Receptor-mediated Signaling Pathway
Cell Motility
Activation Of Immune Response
Immune System Process
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Population Proliferation
Fc Receptor Signaling Pathway
ATP Binding
Cell Activation
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Population Proliferation
Response To Growth Factor
Developmental Process
Nucleotide Binding
Leukocyte Activation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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