PTPRJ and IL2RG

Number of citations of the paper that reports this interaction (PMID 12370829)
19

Data Source:
HPRD (in vitro, in vivo)

		PTPRJ	IL2RG
Gene Name		protein tyrosine phosphatase, receptor type, J	interleukin 2 receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Cell Junction Ruffle Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding
	Biological Process	Vasculogenesis Heart Development Blood Coagulation Negative Regulation Of Cell Proliferation Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Negative Regulation Of Receptor Activity	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway
Pathways			Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) D-dimer levels ( 21502573) Height ( 23563607)
Protein-Protein Interactions		11 interactors: CTNNB1 CTNND1 EGFR IL2RG JUP LAT MET NOP2 PDGFRB PLCG1 SDCBP	24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		5795	3561
HPRD ID		02955	02391
Ensembl ID		ENSG00000149177	ENSG00000147168
Uniprot IDs		Q12913 Q9NPR5	P31785 Q5FC09
PDB IDs		2CFV 2DLE 2NZ6	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of MAPK Cascade Regulation Of Signal Transduction Locomotion Positive Regulation Of Transport Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Cellular Response To Indole-3-methanol Single Organismal Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Signal Transduction Fc-epsilon Receptor Signaling Pathway Response To External Stimulus Chemotaxis Signaling Fc Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Cell Communication Adherens Junction Organization Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Component Movement Immune Response Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorylation Calcium-mediated Signaling Positive Regulation Of Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Estradiol Axon Guidance Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Second-messenger-mediated Signaling Metanephric Nephron Morphogenesis Regulation Of Cell Fate Specification	Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus
Tagcloud ?		10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy cebpe chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition relapsed runx1 sibs tp63 twinned	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy cebpe chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition relapsed runx1 sibs tp63 twinned	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?