FBP2 and BUB1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		FBP2	BUB1
Description		fructose-bisphosphatase 2	BUB1 mitotic checkpoint serine/threonine kinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Z Disc Extracellular Exosome Anchoring Junction	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane
	Molecular Function	Catalytic Activity Protein Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity
	Biological Process	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Fructose 1,6-bisphosphate Metabolic Process	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Gluconeogenesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Caudal middle frontal gyrus volume ( 31530798) Colorectal cancer (alcohol consumption interaction) ( 27723779) Height ( 19893584)
Interacting Genes		19 interacting genes: AURKA AXIN2 BMPR1A BUB1 CHD3 CTNNA1 DLC1 FBXW7 MAP2K4 MLH3 MSH2 NRAS PDGFRL PIK3CA RB1 SMAD2 SMAD4 SRC STK11	64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510
Entrez ID		8789	699
HPRD ID		04322	03907
Ensembl ID		ENSG00000130957	ENSG00000169679
Uniprot IDs		O00757	B4DYG2 O43683
PDB IDs		3IFA 3IFC 4HE0 4HE1 4HE2 5ET5 5ET6 5ET7 5ET8 5K54 5K55 5K56 5L0A 5Q0C	2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Regulation Of Developmental Process Axis Specification Chromosome Organization Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Dorsal/ventral Axis Specification Heart Valve Morphogenesis I-SMAD Binding ATP Binding Intracellular Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Kinase Activity Organelle Organization Regulation Of Organelle Organization Activin Responsive Factor Complex Odontogenesis Protein Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Nucleotide Binding Endoderm Development Regulation Of Chromosome Organization Reproductive Process Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cell Cycle Anatomical Structure Morphogenesis Protein Kinase Activity Centromeric DNA Binding Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding SMAD Binding Regulation Of Cellular Component Organization Response To Growth Factor Mesendoderm Development SMAD Protein Complex Maintenance Of DNA Repeat Elements Regulation Of Signal Transduction	Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle
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