FBP2 and AXIN2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		FBP2	AXIN2
Description		fructose-bisphosphatase 2	axin 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Z Disc Extracellular Exosome Anchoring Junction	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Beta-catenin Destruction Complex Protein-containing Complex
	Molecular Function	Catalytic Activity Protein Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Molecular Adaptor Activity I-SMAD Binding
	Biological Process	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Fructose 1,6-bisphosphate Metabolic Process	Osteoblast Differentiation Somitogenesis Intramembranous Ossification Secondary Heart Field Specification Aortic Valve Morphogenesis Mitral Valve Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Odontogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of DNA Repeat Elements Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Cell Development Response To Steroid Hormone Canonical Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization
Pathways		Gluconeogenesis	TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases			Oligodontia-colorectal cancer syndrome Tooth agenesis; Hypodontia
GWAS		Caudal middle frontal gyrus volume ( 31530798) Colorectal cancer (alcohol consumption interaction) ( 27723779) Height ( 19893584)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: AURKA AXIN2 BMPR1A BUB1 CHD3 CTNNA1 DLC1 FBXW7 MAP2K4 MLH3 MSH2 NRAS PDGFRL PIK3CA RB1 SMAD2 SMAD4 SRC STK11	56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SIAH1 SMAD1 SMAD3 SMAD7 SNCA STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648
Entrez ID		8789	8313
HPRD ID		04322	04935
Ensembl ID		ENSG00000130957	ENSG00000168646
Uniprot IDs		O00757	B7ZKL5 E7ES00 Q9Y2T1
PDB IDs		3IFA 3IFC 4HE0 4HE1 4HE2 5ET5 5ET6 5ET7 5ET8 5K54 5K55 5K56 5L0A 5Q0C	8HEO
Enriched GO Terms of Interacting Partners?		Regulation Of Developmental Process Axis Specification Chromosome Organization Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Dorsal/ventral Axis Specification Heart Valve Morphogenesis I-SMAD Binding ATP Binding Intracellular Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Kinase Activity Organelle Organization Regulation Of Organelle Organization Activin Responsive Factor Complex Odontogenesis Protein Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Nucleotide Binding Endoderm Development Regulation Of Chromosome Organization Reproductive Process Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cell Cycle Anatomical Structure Morphogenesis Protein Kinase Activity Centromeric DNA Binding Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding SMAD Binding Regulation Of Cellular Component Organization Response To Growth Factor Mesendoderm Development SMAD Protein Complex Maintenance Of DNA Repeat Elements Regulation Of Signal Transduction	Beta-catenin Destruction Complex Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Binding Regulation Of Wnt Signaling Pathway I-SMAD Binding Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Organization Heteromeric SMAD Protein Complex Regulation Of Cartilage Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signalosome Centrosome Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Ureteric Bud Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleus Cell Junction Organization Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Mesonephric Epithelium Development Mesonephric Tubule Development Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process SMAD Protein Signal Transduction Positive Regulation Of Catabolic Process Response To Growth Factor Regulation Of Long-term Neuronal Synaptic Plasticity Kidney Epithelium Development Catenin Complex Regulation Of Intracellular Protein Transport Regulation Of Osteoblast Differentiation Identical Protein Binding Protein Binding Positive Regulation Of Cartilage Development Regulation Of Protein Localization To Nucleus Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome SMAD Protein Complex Regulation Of Protein Export From Nucleus
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