CTSL and TG

Number of citations of the paper that reports this interaction (PubMedID 1939080)
0

Data Source:
HPRD (in vitro)

		CTSL	TG
Description		cathepsin L	thyroglobulin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Extracellular Space
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding	Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Thyroid Hormone Generation Signal Transduction Iodide Transport Thyroid Gland Development Regulation Of Myelination Thyroid Hormone Metabolic Process Hormone Biosynthetic Process
Pathways		Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1
Drugs		L-cysteic acid Felbinac Fostamatinib
Diseases			Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS			Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 34103634) Autoimmune thyroid disease ( 32581359) Bone erosion in rheumatoid arthritis ( 28512992) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Graves' disease ( 23612905) Hyperthyroidism ( 30367059) Hypothyroidism ( 27182965) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Temperament ( 22832960) Thyroid stimulating hormone levels ( 30367059) Vitiligo ( 27723757)
Interacting Genes		29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG	10 interacting genes: APCS ASGR1 CANX CRYM CTSD CTSL HSP90B1 HSPA5 LRP2 P4HB
Entrez ID		1514	7038
HPRD ID		00293	01782
Ensembl ID		ENSG00000135047	ENSG00000042832
Uniprot IDs		P07711 Q5T8F0 Q9HBQ7	P01266
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC	6SCJ 7B75
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process	Protein Folding In Endoplasmic Reticulum Endoplasmic Reticulum Chaperone Complex Protein Folding Extracellular Exosome Melanosome Unfolded Protein Binding Receptor-mediated Endocytosis Response To Endoplasmic Reticulum Stress Calcium Ion Binding Protein Catabolic Process Proteolysis Endoplasmic Reticulum Lumen ERAD Pathway Hormone Binding Insulin Metabolic Process Endocytic Vesicle Lumen Endosome Lumen Endocytosis Carbohydrate Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Macromolecule Catabolic Process Hormone Metabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II ATP-dependent Protein Folding Chaperone Peptide Hormone Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Vesicle-mediated Transport Signaling Receptor Ligand Precursor Processing Catabolic Process Import Into Cell Antigen Processing And Presentation Of Exogenous Antigen Proteolysis Involved In Protein Catabolic Process Extracellular Region Delta1-piperideine-2-carboxylate Reductase Activity Thiomorpholine-carboxylate Dehydrogenase Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Protein Folding Chaperone Regulation Of Protein Folding In Endoplasmic Reticulum Antigen Processing And Presentation Of Peptide Antigen Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Maintenance Of Location In Cell Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Asialoglycoprotein Receptor Activity External Side Of Plasma Membrane Endoplasmic Reticulum Aspartic-type Peptidase Activity
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