CTSL and CD7

Number of citations of the paper that reports this interaction (PMID 8666891)
19

Data Source:
HPRD (in vivo)

		CTSL	CD7
Gene Name		cathepsin L	CD7 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding	Receptor Activity
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Activation Homeostasis Of Number Of Cells Within A Tissue
Pathways		Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG	8 interactors: CPTP CTSL LGALS1 NFKBIA PI4KA PIK3R1 SECTM1 SNAP29
Entrez ID		1514	924
HPRD ID		00293	01732
Ensembl ID		ENSG00000135047	ENSG00000173762
Uniprot IDs		P07711 Q9HBQ7	P09564 Q29VG3
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation	Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Immune System Process Apoptotic Process Programmed Cell Death Cell Death Death Signaling Immune System Process Cellular Glucose Homeostasis T Cell Costimulation Cell Communication Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Aggregation NFAT Protein Import Into Nucleus Ceramide 1-phosphate Transport Phosphatidylinositol Phosphorylation Immune Response-regulating Signaling Pathway Regulation Of Transcription Factor Import Into Nucleus Lipid Phosphorylation B Cell Differentiation Regulation Of Immune System Process Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Transcription Factor Import Into Nucleus Macrophage Apoptotic Process Protein Import Into Nucleus Phosphatidylinositol Biosynthetic Process Nuclear Import Cellular Response To Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Activation Of Innate Immune Response Protein Import B Cell Activation Ceramide Transport Protein Localization To Nucleus Regulation Of Protein Import Into Nucleus Negative Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Innate Immune Response Regulation Of Cell-substrate Adhesion Regulation Of Protein Localization To Nucleus
Tagcloud ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	abnormality autologous bm cd19 cd3 cd33 cd34 cd56 cfu clarified conclusively cytopenia dysplastic erythroblasts erythrocyte gemm granulocyte granulocytes lineages megakaryocyte nk pluripotent progenitor smears sorted sorting subpopulations thy1 trisomy
Tagcloud (Difference) ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	abnormality autologous bm cd19 cd3 cd33 cd34 cd56 cfu clarified conclusively cytopenia dysplastic erythroblasts erythrocyte gemm granulocyte granulocytes lineages megakaryocyte nk pluripotent progenitor smears sorted sorting subpopulations thy1 trisomy
Tagcloud (Intersection) ?