CTSL and CSTB

Number of citations of the paper that reports this interaction (PMID 11514663)
2

Data Source:
HPRD (in vitro, in vivo)

		CTSL	CSTB
Gene Name		cathepsin L	cystatin B (stefin B)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Space Nucleolus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Poly(A) RNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Negative Regulation Of Proteolysis
Pathways		Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG	8 interactors: CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2
Entrez ID		1514	1476
HPRD ID		00293	03091
Ensembl ID		ENSG00000135047
Uniprot IDs		P07711 Q9HBQ7	P04080 Q76LA1
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM	1STF 2OCT
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation	Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Epithelial Tube Branching Involved In Lung Morphogenesis Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Lung Morphogenesis Cell Death Death Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Immune Response-regulating Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Catalytic Activity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Response To Organic Substance Toll-like Receptor Signaling Pathway Neuropeptide Catabolic Process Macrophage Apoptotic Process Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteolysis Regulation Of Collagen Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Activation Of Innate Immune Response Regulation Of Cell Death Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Innate Immune Response Catabolic Process Bradykinin Catabolic Process Regulation Of Blood Vessel Remodeling Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Immune Response Response To Stress Regulation Of Cellular Protein Metabolic Process Myeloid Cell Apoptotic Process
Tagcloud ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	ataxia cerebella cerebellar cerebellum compatible connected cystatin electrophysiological epm1 gabaa gabaergic granule hyperexcitable implies interneurons lundborg manifesting myoclonus neuroinflammation p30 p7 pathogenetic pinpointed precedes purkinje recessively recordings terminals unverricht
Tagcloud (Difference) ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	ataxia cerebella cerebellar cerebellum compatible connected cystatin electrophysiological epm1 gabaa gabaergic granule hyperexcitable implies interneurons lundborg manifesting myoclonus neuroinflammation p30 p7 pathogenetic pinpointed precedes purkinje recessively recordings terminals unverricht
Tagcloud (Intersection) ?