CTSL and CST3

Number of citations of the paper that reports this interaction (PMID 10428479)
1

Data Source:
HPRD (in vitro)

		CTSL	CST3
Gene Name		cathepsin L	cystatin C
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding	Beta-amyloid Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Extracellular Fibril Organization Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling
Pathways		Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System	Amyloids
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Cystatin C ( 17903292)
Protein-Protein Interactions		27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG	9 interactors: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115
Entrez ID		1514	1471
HPRD ID		00293	05056
Ensembl ID		ENSG00000135047	ENSG00000101439
Uniprot IDs		P07711 Q9HBQ7	P01034
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM	1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation	Cellular Response To Thyroid Hormone Stimulus Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Response To Thyroid Hormone Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Protein Catabolic Process Positive Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Proteolysis Adaptive Immune Response Antigen Processing And Presentation Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Catabolic Process Immune System Process Immune Response-regulating Signaling Pathway Basement Membrane Disassembly Macrophage Apoptotic Process Adult Locomotory Behavior Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Hormone Stimulus Adult Behavior Myeloid Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Inflammatory Cell Apoptotic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Locomotory Behavior Regulation Of Apoptotic Cell Clearance Negative Regulation Of Endopeptidase Activity Response To Hormone Negative Regulation Of Peptidase Activity
Tagcloud ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic
Tagcloud (Difference) ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic
Tagcloud (Intersection) ?