CTSL and COL18A1

Number of citations of the paper that reports this interaction (PMID 10716919)
59

Data Source:
HPRD (in vitro)

		CTSL	COL18A1
Gene Name		cathepsin L	collagen, type XVIII, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding	Structural Molecule Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Drug Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System	Collagen formation Laminin interactions Collagen degradation Activation of Matrix Metalloproteinases Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS			Hippocampal atrophy ( 22745009)
Protein-Protein Interactions		27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG	8 interactors: CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 KDR MMP2
Entrez ID		1514	80781
HPRD ID		00293	00382
Ensembl ID		ENSG00000135047	ENSG00000182871
Uniprot IDs		P07711 Q9HBQ7	D3DSM4 D3DSM5 P39060
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM	1BNL 3HON 3HSH
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation	Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Catabolic Process Angiogenesis Endoderm Formation Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Collagen Catabolic Process Positive Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Axon Guidance Phototransduction, Visible Light Collagen Metabolic Process Blood Vessel Morphogenesis Retinoid Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Diterpenoid Metabolic Process Multicellular Organismal Metabolic Process Detection Of Visible Light Phototransduction Extracellular Matrix Disassembly Locomotion Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Blood Vessel Development Proteoglycan Metabolic Process Detection Of Light Stimulus Axonogenesis Vasculature Development Heparan Sulfate Proteoglycan Catabolic Process Macrophage Apoptotic Process Axon Development Isoprenoid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Formation Of Primary Germ Layer Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Proteoglycan Catabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Metabolic Process Detection Of Abiotic Stimulus Positive Regulation Of Innate Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation
Tagcloud ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf
Tagcloud (Difference) ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	936cc ag alter c936t carriers chi constitutes d104n determinant dn encoded endostatin eoc exact excess fisher frequencies genotype genotypes inherited polymorphism preliminary reflecting remaining respective restriction tendency toward vegf
Tagcloud (Intersection) ?