PTPN18 and TEC

Number of citations of the paper that reports this interaction (PMID 15588985)
37

Data Source:
HPRD (in vitro)

		PTPN18	TEC
Gene Name		protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	tec protein tyrosine kinase
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Cytoskeleton Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Lipid Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Adaptive Immune Response Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Proliferation Tissue Regeneration Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Signaling by Interleukins Fc epsilon receptor (FCERI) signaling Cytokine Signaling in Immune system FCERI mediated Ca+2 mobilization Interleukin-3, 5 and GM-CSF signaling Innate Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		9 interactors: ABL1 ARHGAP5 CSK ERBB2 GAB1 PSTPIP1 PSTPIP2 SRC TEC	30 interactors: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG GNA12 IKBKG JAK1 JAK2 KIT LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 RHOA SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		26469	7006
HPRD ID		05961	02786
Ensembl ID		ENSG00000072135	ENSG00000135605
Uniprot IDs		Q99952	P42680
PDB IDs		2OC3 4GFU	2LUL
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Innate Immune Response ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Defense Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Wound Healing Regulation Of MAPK Cascade Immune System Process Regulation Of Immune System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Wounding Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cell Proliferation Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Axon Guidance Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Intracellular Signal Transduction Response To Oxidative Stress Central Nervous System Development Organ Development Response To Peptide Hormone Antigen Receptor-mediated Signaling Pathway Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Cellular Response To Organonitrogen Compound	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Signal Transduction Wound Healing Immune Response-regulating Signaling Pathway Response To Organic Substance Signaling Defense Response Response To Wounding Cell Communication Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Organic Substance Regulation Of Immune System Process Cell Activation Regulation Of Signaling Regulation Of Catalytic Activity Cellular Response To Stimulus Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Growth Factor Cell Differentiation Cellular Response To Peptide Hormone Stimulus Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Growth Hormone Stimulus Movement Of Cell Or Subcellular Component Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation
Tagcloud ?		able al authors barcodes barcoding concept dynamic emerging et forms gives modifications nature oncogene paper pest phosphatase proteasomal rather refers regulate relay rise signals throughout trafficking translational ubiquitination wang
Tagcloud (Difference) ?		able al authors barcodes barcoding concept dynamic emerging et forms gives modifications nature oncogene paper pest phosphatase proteasomal rather refers regulate relay rise signals throughout trafficking translational ubiquitination wang
Tagcloud (Intersection) ?