PTPN18 and PSTPIP1

Number of citations of the paper that reports this interaction (PMID 11971877)
51

Data Source:
HPRD (in vivo)

		PTPN18	PSTPIP1
Gene Name		protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	proline-serine-threonine phosphatase interacting protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Stress Fiber Uropod Actomyosin Contractile Ring Cytosol Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding	Actin Binding Protein Binding Protein Phosphatase Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response
Pathways			The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ABL1 ARHGAP5 CSK ERBB2 GAB1 PSTPIP1 PSTPIP2 SRC TEC	29 interactors: ABL1 BUB3 CD2 CD2AP DNM2 FAM90A1 FASLG FBXL18 KHDRBS1 LSM4 MEFV MVP PCDHB14 PRPF31 PTPN12 PTPN18 RTP5 SDCBP SH2D4A SHBG SPG7 TRAF3IP3 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175
Entrez ID		26469	9051
HPRD ID		05961	05891
Ensembl ID		ENSG00000072135	ENSG00000140368
Uniprot IDs		Q99952	O43586
PDB IDs		2OC3 4GFU	2DIL
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Innate Immune Response ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Defense Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Wound Healing Regulation Of MAPK Cascade Immune System Process Regulation Of Immune System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Wounding Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cell Proliferation Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Axon Guidance Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Intracellular Signal Transduction Response To Oxidative Stress Central Nervous System Development Organ Development Response To Peptide Hormone Antigen Receptor-mediated Signaling Pathway Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Cellular Response To Organonitrogen Compound	Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Negative Regulation Of Membrane Tubulation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Nucleation Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Interferon-gamma Secretion Regulation Of Cytoskeleton Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Actin Cytoskeleton Organization Actin Filament-based Movement Actin Filament-based Process Mitotic Cell Cycle Process Substrate-dependent Cell Migration, Cell Extension Cellular Component Assembly Regulation Of Oxidoreductase Activity Regulation Of Cellular Component Organization Mitotic Cell Cycle Signaling Actin Polymerization Or Depolymerization Cytoskeleton Organization Cell Communication Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Signal Transduction Rac Protein Signal Transduction Cell Projection Assembly Actin Filament Organization Mitotic Nuclear Division Nitric Oxide Metabolic Process Regulation Of Catalytic Activity Reactive Nitrogen Species Metabolic Process Endocytosis Cell Cycle Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endothelial Cell Apoptotic Process Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Substrate-dependent Cell Migration Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Nitric-oxide Synthase Activity
Tagcloud ?		able al authors barcodes barcoding concept dynamic emerging et forms gives modifications nature oncogene paper pest phosphatase proteasomal rather refers regulate relay rise signals throughout trafficking translational ubiquitination wang	adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pycr2 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate
Tagcloud (Difference) ?		able al authors barcodes barcoding concept dynamic emerging et forms gives modifications nature oncogene paper pest phosphatase proteasomal rather refers regulate relay rise signals throughout trafficking translational ubiquitination wang	adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pycr2 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate
Tagcloud (Intersection) ?