PTPN18

Name	protein tyrosine phosphatase non-receptor type 18
Structure
Novel Interactors	1 novel interactors: CDK2
Interactors	13 interactors: AATK ABL1 ARHGAP5 CNKSR1 CSK EGFR ERBB2 GAB1 PSTPIP1 PSTPIP2 SNCA SRC TEC
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Blastocyst Formation Protein Dephosphorylation Negative Regulation Of ERBB Signaling Pathway
Pathways	Downregulation of ERBB2 signaling Interleukin-37 signaling
GWAS	No GWAS studies recorded
Entrez ID	26469
HPRD ID	05961
Ensembl ID	ENSG00000072135
Uniprot IDs	Q99952
PDB IDs	2OC3 4GFU 4GFV 4NND
GO Terms Enriched among Interactors ?	Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Perinuclear Region Of Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade ATP Binding Response To Growth Factor Cytoplasm SH2 Domain Binding Protein Phosphorylation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Phosphorylation Transferase Activity Nucleotide Binding Cell-cell Junction ERBB2-EGFR Signaling Pathway Protein Domain Specific Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Transduction Cytosol Cell Surface Receptor Signaling Pathway Cytoskeleton Plasma Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Epinephrine Immune Response-regulating Cell Surface Receptor Signaling Pathway Ruffle Membrane Protein Tyrosine Kinase Activator Activity Positive Regulation Of Locomotion Neuron Apoptotic Process Negative Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Glial Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Endocytosis Proline-rich Region Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Locomotion Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade