KLK13 and A2M

Number of citations of the paper that reports this interaction (PMID 14687906)
2

Data Source:
BioGRID (pull down)

		KLK13	A2M
Gene Name		kallikrein-related peptidase 13	alpha-2-macroglobulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Extracellular Vesicular Exosome	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Hydrolase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Proteolysis Protein Processing	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs			Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		3 interactors: A2M SERPINA1 SERPINF2	93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS
Entrez ID		26085	2
HPRD ID		05693	00072
Ensembl ID			ENSG00000175899
Uniprot IDs		Q86VI7 Q86VI8 Q9UKR3	P01023
PDB IDs			1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Exocytosis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Blood Coagulation Hemostasis Acute-phase Response Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Secretion Regulation Of Proteolysis Cell Activation Response To Wounding Acute Inflammatory Response Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Methanol Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Response To Triglyceride Response To Chromate Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Cellular Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Serine-type Peptidase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Plasminogen Activation Inflammatory Response Regulation Of Catalytic Activity Cellular Localization Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Complement Activation Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin	Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing
Tagcloud ?		10ra 10rb a2m abolish alpha2 destructive details disrupt edge enrich enriching exploited favoring hampering hinders immuno kallikrein likewise macroglobulin matching missing modulatory neighbor network paths prism representation shed weaken	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Difference) ?		10ra 10rb abolish alpha2 destructive details disrupt edge enrich enriching exploited favoring hampering hinders immuno kallikrein likewise matching missing modulatory neighbor network paths prism representation shed weaken	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Intersection) ?		a2m macroglobulin