KLK13 and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 14687906)
0

Data Source:
BioGRID (pull down)

		KLK13	SERPINA3
Description		kallikrein related peptidase 13	serpin family A member 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Protein Processing Protein Maturation	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Formation of the cornified envelope	Platelet degranulation Neutrophil degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein levels ( 29403010)
Interacting Genes		3 interacting genes: A2M SERPINA3 SERPINF2	29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		26085	12
HPRD ID		05693	00120
Ensembl ID		ENSG00000167759	ENSG00000196136
Uniprot IDs		M0R218 Q5BQ99 Q86VI7 Q9UKR3	P01011
PDB IDs			1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Blood Microparticle Acute-phase Response Endopeptidase Inhibitor Activity Extracellular Matrix Acute Inflammatory Response Protease Binding Negative Regulation Of Complement Activation, Lectin Pathway Interleukin-8 Binding Lactose Synthase Activity N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Plasminogen Activation Galactosyltransferase Activity Fibrinogen Complex Extracellular Space System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Cerebellar Purkinje Cell Layer Development Negative Regulation Of Fibrinolysis Negative Regulation Of Complement Activation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Complement Activation Maintenance Of Gastrointestinal Epithelium Inflammatory Response Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Blood Coagulation Fibrinolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Collagen Biosynthetic Process Extracellular Exosome Extracellular Region Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Coagulation Epithelial Structure Maintenance Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Systemic Arterial Blood Pressure Growth Factor Binding Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath
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