USP49 and MED8

Number of citations of the paper that reports this interaction (PMID 14576168)
11

Data Source:
HPRD (in vivo)

		USP49	MED8
Gene Name		ubiquitin specific peptidase 49	mediator complex subunit 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Mediator Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Histone Binding	RNA Polymerase II Transcription Cofactor Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Protein Ubiquitination
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 23263863 20139978) Red blood cell count ( 20139978)
Protein-Protein Interactions		6 interactors: HIST2H2BE MED17 MED18 MED8 RBCK1 TRIM35	31 interactors: APP ARRB2 CCNC CDK8 CTDP1 HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 TCEB1 THOC7 UBALD1 USP49
Entrez ID		25862	112950
HPRD ID		10075	06991
Ensembl ID		ENSG00000164663	ENSG00000159479
Uniprot IDs		Q70CQ1	Q96G25
PDB IDs
Enriched GO Terms of Interacting Partners?			Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Biosynthetic Process Stem Cell Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Androgen Receptor Signaling Pathway Stem Cell Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Binding Regulation Of Cell Differentiation Developmental Growth Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Cell Development Negative Regulation Of Fibroblast Proliferation Axis Elongation Cellular Response To Transforming Growth Factor Beta Stimulus Thyroid Hormone Mediated Signaling Pathway
Tagcloud ?		affects cotranscriptional deubiquitinase deubiquitinates deubiquitination dramatically eukaryotes exons h2b identifies intronic knockdown like1 modulated nascent nucleosome peptidase purification relatively ruvb rvb1 splicing sug1 u1a u2b ubiquitination uh2b uncovers upstream	antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk
Tagcloud (Difference) ?		affects cotranscriptional deubiquitinase deubiquitinates deubiquitination dramatically eukaryotes exons h2b identifies intronic knockdown like1 modulated nascent nucleosome peptidase purification relatively ruvb rvb1 splicing sug1 u1a u2b ubiquitination uh2b uncovers upstream	antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk
Tagcloud (Intersection) ?