MED8 and MED25

Number of citations of the paper that reports this interaction (PubMedID 14638676)
0

Data Source:
HPRD (in vivo)

		MED8	MED25
Description		mediator complex subunit 8	mediator complex subunit 25
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Core Mediator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Binding Protein Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Mediator Complex Assembly
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		33 interacting genes: APP ARRB2 CCNC CDK8 CEBPA CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 PRKAR1B SNTA1 THOC7 UBALD1 USP49	38 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SENP3 SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2
Entrez ID		112950	81857
HPRD ID		06991	14380
Ensembl ID		ENSG00000159479	ENSG00000104973
Uniprot IDs		Q96G25	M0QZQ2 Q71SY5
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	2KY6 2L23 2L6U 2XNF 7EMF 7LBM 8GXQ 8GXS 8T9D
Enriched GO Terms of Interacting Partners?		Mediator Complex Core Mediator Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Protein-DNA Complex Assembly Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Ligase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Somatic Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Protein-containing Complex Organization Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Nucleoplasm Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Stem Cell Population Maintenance Maintenance Of Cell Number Positive Regulation Of Metabolic Process Nuclear Vitamin D Receptor Binding Ubiquitin Protein Ligase Activity Nucleus Transcription Initiation At RNA Polymerase II Promoter CKM Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nuclear Thyroid Hormone Receptor Binding DNA-templated Transcription Initiation Cellular Component Assembly	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nuclear Receptor Activity Core Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Mediator Complex Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription Coregulator Activity Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Intracellular Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleoplasm Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway COPII Vesicle Coating Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription
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