MED8 and PEX14

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED8	PEX14
Gene Name		mediator complex subunit 8	peroxisomal biogenesis factor 14
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Intracellular Nucleus Nucleolus Peroxisome Peroxisomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	Transcription Corepressor Activity Receptor Binding Protein Binding Microtubule Binding Protein N-terminus Binding Beta-tubulin Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Protein Ubiquitination	Protein Complex Assembly Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization Negative Regulation Of Protein Homotetramerization
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Breast cancer ( 23535729 23535733) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		31 interactors: APP ARRB2 CCNC CDK8 CTDP1 HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 TCEB1 THOC7 UBALD1 USP49	8 interactors: HDAC1 MED8 NFE2 PEX19 PEX5 PEX7 SMARCC2 ZHX1
Entrez ID		112950	5195
HPRD ID		06991	03477
Ensembl ID		ENSG00000159479	ENSG00000142655
Uniprot IDs		Q96G25	F5H4J2 O75381
PDB IDs			2W84 2W85
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Biosynthetic Process Stem Cell Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Androgen Receptor Signaling Pathway Stem Cell Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Binding Regulation Of Cell Differentiation Developmental Growth Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Cell Development Negative Regulation Of Fibroblast Proliferation Axis Elongation Cellular Response To Transforming Growth Factor Beta Stimulus Thyroid Hormone Mediated Signaling Pathway	Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisome Organization Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Protein Import Into Peroxisome Membrane Peroxisomal Membrane Transport Protein Import Into Peroxisome Matrix Nucleosome Disassembly Protein Import Fatty Acid Beta-oxidation Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process ATP-dependent Chromatin Remodeling Protein Targeting Negative Regulation Of Lipid Binding Transcription, DNA-templated RNA Biosynthetic Process Protein Localization To Organelle Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Nucleosome Organization Cellular Lipid Catabolic Process Chromatin Assembly Or Disassembly Cellular Metabolic Process Cytoplasmic Transport Organ Development Protein Targeting To Membrane Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Matrix, Docking Neuron Migration Biosynthetic Process Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Lipid Modification Carboxylic Acid Catabolic Process Negative Regulation Of Protein Homooligomerization Ether Lipid Biosynthetic Process Protein Complex Disassembly Central Nervous System Neuron Differentiation Cell Differentiation
Tagcloud ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex11 pex28 pex3 pex5 pex6 pex7 pex8 pox1 puf5 rbp rfp
Tagcloud (Difference) ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex11 pex28 pex3 pex5 pex6 pex7 pex8 pox1 puf5 rbp rfp
Tagcloud (Intersection) ?