MED8 and MED30

Number of citations of the paper that reports this interaction (PMID 12584197)
12

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MED8	MED30
Gene Name		mediator complex subunit 8	mediator complex subunit 30
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Nucleus Nucleoplasm Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Protein Ubiquitination	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Kawasaki disease ( 22446961)
Protein-Protein Interactions		31 interactors: APP ARRB2 CCNC CDK8 CTDP1 HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 TCEB1 THOC7 UBALD1 USP49	13 interactors: APP DOCK8 KRTAP10-9 MED17 MED22 MED27 MED28 MED4 MED8 MED9 MTA2 PCBD2 SS18L1
Entrez ID		112950	90390
HPRD ID		06991	11631
Ensembl ID		ENSG00000159479	ENSG00000164758
Uniprot IDs		Q96G25	Q96HR3
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Biosynthetic Process Stem Cell Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Androgen Receptor Signaling Pathway Stem Cell Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Binding Regulation Of Cell Differentiation Developmental Growth Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Cell Development Negative Regulation Of Fibroblast Proliferation Axis Elongation Cellular Response To Transforming Growth Factor Beta Stimulus Thyroid Hormone Mediated Signaling Pathway	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process DNA-templated Transcription, Initiation Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Stem Cell Maintenance Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Stem Cell Development Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Stem Cell Differentiation Positive Regulation Of Metabolic Process Memory T Cell Proliferation Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Synaptic Growth At Neuromuscular Junction Cell Development Collateral Sprouting In Absence Of Injury Cell Recognition Dendrite Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Smooth Muscle Cell Differentiation
Tagcloud ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	abundant attenuated branching communicates communications double ductal e2f1 employing ers functionally gland glands haploinsufficient heterozygous knockout lactation luciferase luminal mammary med1 med24 mediator normally profound pubertal puberty retardation submodule
Tagcloud (Difference) ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	abundant attenuated branching communicates communications double ductal e2f1 employing ers functionally gland glands haploinsufficient heterozygous knockout lactation luciferase luminal mammary med1 med24 mediator normally profound pubertal puberty retardation submodule
Tagcloud (Intersection) ?