MED8 and MED28

Number of citations of the paper that reports this interaction (PMID 15175163)
80

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		MED8	MED28
Gene Name		mediator complex subunit 8	mediator complex subunit 28
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Membrane Mediator Complex Cortical Actin Cytoskeleton
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	Actin Binding Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Protein Ubiquitination	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Stem Cell Maintenance Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: APP ARRB2 CCNC CDK8 CTDP1 HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 TCEB1 THOC7 UBALD1 USP49	14 interactors: FYN GRB2 KLHL12 LCK MAGEA11 MED30 MED8 MED9 NF2 PRMT6 PUF60 SPERT SRC USHBP1
Entrez ID		112950	80306
HPRD ID		06991	14381
Ensembl ID		ENSG00000159479
Uniprot IDs		Q96G25	Q9H204
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Biosynthetic Process Stem Cell Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Androgen Receptor Signaling Pathway Stem Cell Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Binding Regulation Of Cell Differentiation Developmental Growth Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Cell Development Negative Regulation Of Fibroblast Proliferation Axis Elongation Cellular Response To Transforming Growth Factor Beta Stimulus Thyroid Hormone Mediated Signaling Pathway	T Cell Costimulation Regulation Of Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Viral Process Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Gene Expression Blood Coagulation Phosphatidylinositol-mediated Signaling Hemostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Response To Peptide Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Defense Response To Virus By Virus Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Protein Autophosphorylation Regulation Of Body Fluid Levels Negative Regulation Of Signaling Response To Mechanical Stimulus Response To Growth Factor
Tagcloud ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	aspect blocked concomitant construct cytoskeleton dead ectopic eg exhibits exogenous grb2 interfering invasion magicin map2k1 mediator mek1 merlin metalloproteinase migration mmp2 potentiated presumably recovered reinforcing repressor rescued stimulate suppression
Tagcloud (Difference) ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	aspect blocked concomitant construct cytoskeleton dead ectopic eg exhibits exogenous grb2 interfering invasion magicin map2k1 mediator mek1 merlin metalloproteinase migration mmp2 potentiated presumably recovered reinforcing repressor rescued stimulate suppression
Tagcloud (Intersection) ?