USP49

Name	ubiquitin specific peptidase 49
Structure	No pdb structure
Interactors	11 interactors: H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Chromatin Organization Chromatin Remodeling MRNA Processing Proteolysis RNA Splicing Protein Deubiquitination Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways	Ub-specific processing proteases
GWAS	Cutaneous psoriasis ( 26626624 ) Hip circumference adjusted for BMI ( 34021172 ) Mean corpuscular hemoglobin ( 32888494 20139978 ) Mean corpuscular volume ( 23263863 27863252 32888494 20139978 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 ) Red blood cell count ( 27863252 20139978 32888494 ) Reticulocyte count ( 32888494 ) Skin aging (microtopography measurement) ( 28502801 ) Sleep duration (short sleep) ( 30846698 )
Entrez ID	25862
HPRD ID	10075
Ensembl ID	ENSG00000164663
Uniprot IDs	Q70CQ1
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Activity Protein-containing Complex Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Ubiquitination Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nicotinamide Phosphoribosyltransferase Activity Cyclic-di-GMP Binding STING Complex Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Defense Response Positive Regulation Of Macromolecule Metabolic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate 2',3'-cyclic GMP-AMP Binding Post-translational Protein Modification Negative Regulation Of Fermentation