MED8 and MED26

Number of citations of the paper that reports this interaction (PMID 15175163)
80

Data Source:
HPRD (in vitro)

		MED8	MED26
Gene Name		mediator complex subunit 8	mediator complex subunit 26
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Nucleoplasm Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	RNA Polymerase II Transcription Cofactor Activity DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Protein Ubiquitination	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: APP ARRB2 CCNC CDK8 CTDP1 HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 TCEB1 THOC7 UBALD1 USP49	7 interactors: CDK8 CTDP1 MED12 MED8 MED9 RBP1 SREBF1
Entrez ID		112950	9441
HPRD ID		06991	05437
Ensembl ID		ENSG00000159479	ENSG00000105085
Uniprot IDs		Q96G25	O95402
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Biosynthetic Process Stem Cell Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Androgen Receptor Signaling Pathway Stem Cell Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Binding Regulation Of Cell Differentiation Developmental Growth Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Cell Development Negative Regulation Of Fibroblast Proliferation Axis Elongation Cellular Response To Transforming Growth Factor Beta Stimulus Thyroid Hormone Mediated Signaling Pathway	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process DNA-templated Transcription, Initiation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Axis Elongation Involved In Somitogenesis Establishment Of Sertoli Cell Barrier Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Regulation Of Heart Rate By Chemical Signal Histone H4-K20 Trimethylation Vitamin A Metabolic Process Cellular Metabolic Process Exit From Mitosis Histone H3-K9 Trimethylation Histone H3-K4 Trimethylation Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Triglyceride Biosynthetic Process Histone H4-K20 Methylation Positive Regulation Of Histone Deacetylation Regulation Of Cholesterol Biosynthetic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Sertoli Cell Development Response To Food Histone H3-K9 Methylation
Tagcloud ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	alter arm bipartite coupling crystallographic cuniculi elongation elongin enables encephalitozoon export heat homologous iws1 med13 mediator networks phosphoprotein recognizes remodelling repeats reveal saga spt6 spt6n spt8 subdomain subdomains tfiis
Tagcloud (Difference) ?		antigenic arising asxl1 bands casp5 cms colon colonic crebbp decay encode ep300 examples exon fbxl3 frameshift microsatellite microsatellites msh3 msi neo nmd nonsense rgs12 sfrs12ip1 targetable termini transcripts ttk	alter arm bipartite coupling crystallographic cuniculi elongation elongin enables encephalitozoon export heat homologous iws1 med13 mediator networks phosphoprotein recognizes remodelling repeats reveal saga spt6 spt6n spt8 subdomain subdomains tfiis
Tagcloud (Intersection) ?