USP49 and MED18

Number of citations of the paper that reports this interaction (PubMedID 12584197)
0

Data Source:
HPRD (in vivo, in vitro)

		USP49	MED18
Description		ubiquitin specific peptidase 49	mediator complex subunit 18
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity	Transcription Coregulator Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Chromatin Organization Chromatin Remodeling MRNA Processing Proteolysis RNA Splicing Protein Deubiquitination Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Ub-specific processing proteases	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Cutaneous psoriasis ( 26626624) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 20139978) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 20139978 32888494) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
Interacting Genes		11 interacting genes: H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774	9 interacting genes: AFMID CAMK2B HOMEZ MED20 MED31 MED9 TEPSIN TRIM39 USP49
Entrez ID		25862	54797
HPRD ID		10075	17476
Ensembl ID		ENSG00000164663	ENSG00000130772
Uniprot IDs		Q70CQ1	Q9BUE0
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Activity Protein-containing Complex Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Ubiquitination Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nicotinamide Phosphoribosyltransferase Activity Cyclic-di-GMP Binding STING Complex Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Defense Response Positive Regulation Of Macromolecule Metabolic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate 2',3'-cyclic GMP-AMP Binding Post-translational Protein Modification Negative Regulation Of Fermentation	Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Protein-DNA Complex Assembly Arylformamidase Activity Coated Vesicle Membrane Histone H2B Deubiquitinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex L-tryptophan Catabolic Process To Kynurenine
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